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Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin- Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin

Fernandez, Gimena; Cabral, Agustina Soledad; Cornejo, María Paula; de Francesco, Pablo Nicolás; Garcia Romero, Guadalupe; Reynaldo, Mirta Beatriz; Perello, Mario (Wiley Blackwell Publishing, Inc, 2016-02)

Ghrelin is a stomach-derived octanoylated peptide hormone that plays a variety of well-established biological roles acting via its specific receptor known as growth hormone secretagogue receptor (GHSR). In plasma, a ...

Des-acyl ghrelin and ghrelin O-acyltransferase regulate hypothalamic-pituitary-adrenal axis activation and anxiety in response to acute stress

Stark, Romana; Santos, Vanessa V.; Geenen, Bram; Cabral, Agustina Soledad; Dinan, Tara; Bayliss, Jacqueline A.; Lockie, Sarah H.; Reichenbach, Alex; Lemus, Moyra B.; Perello, Mario; Spencer, Sarah J.; Kozicz, Tamas; Andrews, Zane B. (Endocrine Society, 2016-10)

Ghrelin exists in two forms in circulation, acyl ghrelin and des-acyl ghrelin, both of which have distinct and fundamental roles in a variety of physiological functions. Despite this fact, a large proportion of papers ...

Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: Correlation with age and insulin resistance

Fittipaldi, Antonela Soledad; Hernandez, Julieta; Castrogiovanni, Daniel Cayetano; Lufrano, Daniela; de Francesco, Pablo Nicolás; Garrido, Verónica; Vitaux, Patrick; Fasano, María Victoria; Fehrentz, Jean Alain; Fernández, Adriana; Andreoli, María F.; Perello, Mario (BioScientifica, 2019-11)

Objective: The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin ...

Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance

Fittipaldi, Antonela Soledad; Hernández, Julieta M.; Castrogiovanni, Daniel Cayetano; Lufrano, Daniela; De Francesco, Pablo Nicolás; Garrido, Verónica; Vitaux, Patrick; Fasano, María Victoria; Fehrentz, Jean Alain; Fernández, Adriana; Andreoli, María F.; Perelló, Mario Carlos (2020)

Determinação da grelina acilada e dos ácidos graxos livres durante teste de tolerância oral à glicose na gestação normal e na gestação complicada por diabetes gestacional

Ricardo Barsaglini da Silva Leite (Universidade Federal de Minas GeraisUFMG, 2009-11-04)

The gestational diabetes is admittedly an insulin resistant state. It is thus an excellent model to study the pattern of many metabolic values that show differences in insulin resistants states. These differences occur ...

Fasting Upregulates npy, agrp, and ghsr without Increasing Ghrelin Levels in Zebrafish (Danio rerio) Larvae

Opazo, Rafael; Plaza Parrochia, Francisca; Cardoso Dos Santos, Gustavo R.; Carneiro, Gabriel R.A.; Sardela, Vinicius F.; Romero Ormazábal, Jaime; Valladares Boasi, Luis (Frontiers Media S.A., 2019)

Food intake in fish and mammals is orchestrated by hypothalamic crosstalk between orexigenic (food intake stimulation) and anorexigenic (food intake inhibition) signals. Some of these signals are released by peripheral ...