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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
(Pergamon-Elsevier Science Ltd, 2004-04)
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases ...
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
The Catalytic Subunit of cAMP‐Dependent Protein Kinase from Ascaris suum The Cloning and Structure of a Novel Subtype of Protein Kinase A
(1995)
A complete cDNA clone encoding the catalytic subunit of cAMP‐dependent protein kinase of Ascaris suum was constructed from two overlapping partial clones. The encoded sequence of 337 ammo acids is 48 % identical with the ...
Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad
Glycogen synthase kinase (GSK)-3α/β and the double-stranded RNA-dependent kinase PKR are two sentinel
kinases that carry-out multiple similar yet distinct functions in both the cytosol and the nucleus. While these
kinases ...
The ADP-dependent Sugar Kinase Family: Kinetic and Evolutionary Aspects
(JOHN WILEY & SONS INC, 2009-03-28)
Some archaea of the Euryarchaeota present a unique version
of the Embden–Meyerhof pathway where glucose and fructose-
6-phosphate are phoshporylated using ADP instead of ATP as
the phosphoryl donor. These are the only ...
The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae
(Portland Press, 2012-09)
PDK1 (phosphoinositide-dependent protein kinase 1) phosphorylates and activates PKA (cAMP-dependent protein kinase) in vitro. Docking of the HM (hydrophobic motif) in the C-terminal tail of the PKA catalytic subunits on ...
Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling
(Springer, 2019)
Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector ...