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Functional significance of eIF5A and its hypusine modification in eukaryotes
(Springer, 2010-02-01)
The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is ...
Functional significance of eIF5A and its hypusine modification in eukaryotes
(Springer, 2010-02-01)
The unusual basic amino acid, hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is ...
The Deoxyhypusine Synthase Mutant dys1-1 Reveals the Association of eIF5A and Asc1 with Cell Wall Integrity
(2013-04-01)
The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein among archaea and eukaryotes that has recently been implicated in the elongation step of translation. eIF5A undergoes an essential ...
The Deoxyhypusine Synthase Mutant dys1-1 Reveals the Association of eIF5A and Asc1 with Cell Wall Integrity
(2013-04-01)
The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein among archaea and eukaryotes that has recently been implicated in the elongation step of translation. eIF5A undergoes an essential ...
Discovery of new inhibitors of deoxyhypusine synthase (DHPS): Virtual screening and biochemical evaluation
(Amer Chemical Soc, 2014-08-10)
Hypusine Plays a Role in the Translation of Short mRNAs and Mediates the Polyamine and Autophagy Pathways in Saccharomyces Cerevisiae
(2021-01-01)
The cell highly regulates the translational process aiming to maintain cellular stability and viability for mechanisms at the transcriptional, translational, or metabolic level, such as the control of transcripts forwarded ...
Mutational analyses of human eIF5A-1-identification of amino acid residues critical for eIF5A activity and hypusine modification
(Blackwell Publishing, 2008-01-01)
The eukaryotic translation initiation factor 5A (eIF5A) is the only protein that contains hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational ...
Mutational analyses of human eIF5A-1-identification of amino acid residues critical for eIF5A activity and hypusine modification
(Blackwell Publishing, 2008-01-01)
The eukaryotic translation initiation factor 5A (eIF5A) is the only protein that contains hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational ...