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Mechanisms regulating dendritic arbor patterning
(Springer, 2017-12)
The nervous system is populated by diverse types of neurons, each of which has dendritic trees with strikingly different morphologies. These neuron-specific morphologies determine how dendritic trees integrate thousands ...
The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
(Oxford University Press, 2017-04-01)
Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...
The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
(Oxford University Press, 2017-04)
Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...
Descriptive findings on the morphology of dendritic spines in the rat medial amygdala
(ELSEVIER IRELAND LTD, 2010)
The rat posterodorsal medial amygdala (MePD) is a brain area in which gonadal hormones induce notable plastic effects in the density of dendritic spines. Dendritic spines are post-synaptic specializations whose shape and ...
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
(2015)
Wnt signaling regulates synaptic development and function and contributes to the fine-tuning of the molecular and morphological differentiation of synapses. We have shown previously that Wnt5a activates non-canonical Wnt ...
Rapid signaling of strogen to neuronal dendrite spine formation
(Lambert Academic Publishing, 2012)
Estrogens are important regulators of neuronal cell morphology and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling ...
The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM
(Company of Biologists, 2016-11)
The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor ...
Actin filaments and microtubules in dendritic spines
(International Society for Neurochemistry, 2013-07)
endritic spines are small protrusions emerging from their parent dendrites, and their morphological changes are involved in synaptic plasticity. These tiny structures are composed of thousands of different proteins belonging ...
Cdk5 is essential for amphetamine to increase dendritic spine density in hippocampal pyramidal neurons
(Frontiers Research Foundation, 2017-11)
Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic ...
Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
(American Society for Biochemistry and Molecular Biology, 2016-09)
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that regulates dendritic spine formation in rodent hippocampal ...