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Development and Validation of a Novel HPLC Method for the Analysis and Quantification of Dehydroleucodine in Plant Extracts
(Bentham Science Publishers, 2018-12)
Background: Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser. Distinctive biological and pharmacological activities have been shown extensively for this molecule. Only one analytical ...
Biomedical properties of sesquiterpene lactones, with a focus on dehydroleucodine
(Natural Products, 2017-03)
Dehydroleucodine, a sesquiterpene lactone, belongs to the terpenoid class of secondary metabolites. Dehydroleucodine and other Artemisia-derivedphytochemicals evolved numerous biodefenses that were first co-opted for human ...
Chemical activation in Rhinella arenarum oocytes: effect of dehydroleucodine (DhL) and its hydrogenated derivative (2H-DhL)
(Cambridge University Press, 2014-11)
Mature oocytes are arrested in metaphase II due to the presence of high levels of active maturation promoting factor (MPF). After fertilization, active MPF levels decline abruptly, enabling oocytes to complete meiosis II. ...
Natural α,β-unsaturated lactones inhibit neuropeptide-induced mast cell activation in an in vitro model of neurogenic inflammation
(Birkhauser Verlag Ag, 2020-10)
Introduction: Mast cells are involved in not only inducing, but also maintaining neurogenic inflammation and neuropathic pain. In previous work, we have demonstrated that dehydroleucodine, xanthatin and 3-benzyloxymethyl ...
Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest
(John Wiley & Sons Ltd, 2018-08)
Aberrant levels of preadipocyte differentiation, triggered by adipocyte hyperplasia and hypertrophy, results in the obesogenic phenotype. Obesity is a risk factor for several metabolic disorders. In this paper, dehydroleucodine ...
A novel insight into Dehydroleucodine mediated attenuation of Pseudomonas aeruginosa virulence mechanism
(Indawi, 2015-12)
Increasing resistance of Pseudomonas aeruginosa (P. aeruginosa) to conventional treatments demands the search for noveltherapeutic strategies. In this study, the antimicrobial activity of dehydroleucodine (DhL), a sesquiterpene ...
The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers
(Public Library Of Science, 2013-01-14)
Sesquiterpene lactones (SLs) are plant-derived compounds that display anti-cancer effects. Some SLs derivatives have a marked killing effect on cancer cells and have therefore reached clinical trials. Little is known ...
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis
(Elsevier, 2016)
Malignant melanoma represents the fastest growing public health risk of all cancer types worldwide.
Several strategies and anti-cancer drugs have been used in an effort to improve treatments, but the development
of ...
Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage
(Bentham Science Publishers, 2010-06)
Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. ...
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
(Elsevier Science, 2012-05)
Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B ...