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SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses
(Elsevier, 2007-02)
Immune cells are modulated through the crosslinking of receptors named “immunoreceptors”. Ligation of immunoreceptors by their ligands induces a tyrosine-phosphorylation signal that is essential for cell activation or ...
SLAM and CD31: Signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses
(Elsevier, 2007-02)
Immune cells are modulated through the crosslinking of receptors named "immunoreceptors". Ligation of immunoreceptors by their ligands induces a tyrosine-phosphorylation signal that is essential for cell activation or ...
The Potential Role of Suppressors of Cytokine Signaling in the Attenuation of Inflammatory Reaction and Alveolar Bone Loss Associated with Apical Periodontitis
(ELSEVIER SCIENCE INC, 2008)
Inflammatory cytokines contribute to periapical tissue destruction. Their activity is potentially regulated by suppressors of cytokine signaling (SOCS), which down-regulate signal transduction as part of an inhibitory ...
Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats
(Pergamon-Elsevier B.V. Ltd, 2011-10-01)
Objective: : Evaluate expression of inducible negative regulators of JAK/STAT pathway and their target proteins during the course of ligature-induced experimental periodontal disease in rats.Design: : Rats were sacrificed ...
Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats
(Pergamon-Elsevier B.V. Ltd, 2011-10-01)
Objective: : Evaluate expression of inducible negative regulators of JAK/STAT pathway and their target proteins during the course of ligature-induced experimental periodontal disease in rats.Design: : Rats were sacrificed ...
Nervous and immune systems signals and connections: Cytokines in hippocampus physiology and pathology
(Elsevier B.V., 2014-09-01)
Signaling through secretion of small molecules is a hallmark of both nervous and immune systems. the scope and influence of the intense message exchange between these two complex systems are only now becoming objects of ...
Inhibition of cytokine signaling by ruxolitinib and implications for COVID19 treatment
Approximately 15% of patients with coronavirus disease 2019 (COVID-19) experience severe disease, and 5%
progress to critical stage that can result in rapid death. No vaccines or antiviral treatments have yet proven
effective ...
Curcurnin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1,-3 and p38 MAPK
(Elsevier B.V., 2013-10-01)
Curcumin is the active compound in the extract of Curcuma longa rhizomes with anti-inflammatory properties mediated by inhibition of intracellular signalling. SOCS and MAP-Kinases are involved in the signalling events ...
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
(2012)
Background/aim: Possible etiologies of idiopathic short stature (ISS) include a range of conditions, some of which may be caused by defects in the modulation of the growth hormone (GH)-signaling pathway. The Janus kinase/signal ...