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Corneal angiogenesis modulation by cysteine cathepsins: in vitro and in vivo studies
(Elsevier B.V., 2015-05-01)
Corneal avascularization is essential for normal vision. Several antiangiogenic factors were identified in cornea such as endostatin and angiostatin. Cathepsin V, which is highly expressed in the cornea, can hydrolyze human ...
Role of cathepsin S In periodontal wound healing-an in vitro study on human PDL cells
(2018-04-05)
Background: Cathepsin S is a cysteine protease, which is expressed in human periodontal ligament (PDL) cells under inflammatory and infectious conditions. This in vitro study was established to investigate the effect of ...
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives
(Springer, 2014-06-01)
Several cellular disorders have been related to the overexpression of the cysteine protease cathepsin B (CatB), such as rheumatic arthritis, muscular dystrophy, osteoporosis, Alzheimer's disease, and tumor metastasis. ...
Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins
(Sage Publications IncThousand OaksEUA, 2012)
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated. It was possible to identify the relevance of structural ...
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S
(Elsevier B.V., 2011-03-15)
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated. It was possible to identify the relevance of structural ...
Defining the substrate specificity of mouse cathepsin P
(Elsevier B.V., 2005-03-01)
Cathepsin P is a recently discovered placental cysteine protease that is structurally related to the more ubiquitously expressed, broad-specificity enzyme, cathepsin L. We studied the substrate specificity requirements of ...
Cathepsin X binds to cell surface heparan sulfate proteoglycans
(Elsevier B.V., 2005-04-15)
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of ...
The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Cathepsin L-like proteinases (CAL) are major digestive proteinases in the beetle Tenebrio molitor. Procathepsin Ls 2 (pCAL2) and 3 (pCAL3) were expressed as recombinant proteins in Escherichia coil, purified and activated ...
Cyclic, Linear, Cycloretro-Isomer, and Cycloretro-Inverso Peptides Derived from the C-Terminal Sequence of Bradykinin as Substrates or Inhibitors of Serine and Cysteine Proteases
(Springer, 2004-05-01)
We investigated the inhibition of trypsin, human tissue (hK1) and human plasma kallikrein (HuPK), papain, and cathepsin L, B, and X by synthetic cyclic, cycloretro-isomer, cycloretro-inverso, and linear peptides derived ...