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Oral cancer and cyclins (multiple letters)
(2004-07-01)
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas
(Elsevier Gmbh, Urban & Fischer Verlag, 2011-01-01)
A decrease in the level of the ROC1 protein, which is involved in cyclin D1 degradation, might explain an increase in cyclin D1 protein in the absence of gene overexpression. This study aimed to investigate the relationship ...
Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma
(Springer, 2012)
The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. ...
Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas
(Elsevier Gmbh, Urban & Fischer Verlag, 2014)
Tl(I) and Tl(III) alter the expression of EGF-dependent signals and cyclins required for pheochromocytoma (PC12) cell-cycle resumption and progression
(Wiley, 2015-08)
The effects of thallium [Tl(I) and Tl(III)] on the PC12 cell cycle were evaluated without (EGF−) or with (EGF+) media supplementation with epidermal growth factor (EGF). The following markers of cell-cycle phases were ...
Oxidation of proline from the cyclin-binding motif in maize CDKA;1 results in lower affinity with its cyclin regulatory subunit
(Pergamon-Elsevier Science Ltd, 2019-11)
Cyclin dependent kinase A; 1 (CDKA; 1) is essential in G1/S transition of cell cycle and its oxidation has been implicated in cell cycle arrest during plant abiotic stress. In the present study, an evaluation at the molecular ...
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b)
(Wiley, 2009-06)
Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870). Epidemiological ...