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Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Estadual Paulista (Unesp) (Taylor & Francis Ltd, 2010-02-01)

Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. The aim of this work was to assess whether NF and its derivative ...

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Estadual Paulista (Unesp) (Taylor & Francis Ltd, 2010-02-01)

Convergent synthesis and cruzain inhibitory activity of novel 2-(N `-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines

ZANATTA, Nilo; AMARAL, Simone S.; SANTOS, Josiane M. dos; MELLO, Debora L. de; FERNANDES, Liana da S.; BONACORSO, Helio G.; MARTINS, Marcos A. P.; ANDRICOPULO, Adriano Defini; BORCHHARDT, Deise M. (PERGAMON-ELSEVIER SCIENCE LTD, 2008)

To search for new cruzain inhibitors, the synthesis of a series of novel 2-(N`-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines in a convergent manner is presented. The cruzain inhibitory activity of some of these ...

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

TROSSINI, Gustavo H. G.; MALVEZZI, Alberto; AMARAL, Antonia T-do; RANGEL-YAGUI, Carlota Oliveira; IZIDORO, Mario A.; CEZARI, Maria Helena S.; JULIANO, Luiz; CHIN, Chung Man; MENEZES, Carla M. S.; FERREIRA, Elizabeth Igne (TAYLOR & FRANCIS LTD, 2010)

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Trossini, Gustavo H. G.; Malvezzi, Alberto; T-do Amaral, Antonia; Rangel-Yagui, Carlota Oliveira; Izidoro, Mario A. [UNIFESP]; Cezari, Maria Helena S. [UNIFESP]; Juliano, Luiz [UNIFESP]; Chin, Chung Man; Menezes, Carla M. S.; Ferreira, Elizabeth Igne (Taylor & Francis Ltd, 2010-02-01)

Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. the aim of this work was to assess whether NF and its derivative ...

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Trossini, Gustavo H. G.; Malvezzi, Alberto; T-do Amaral, Antonia; Rangel-Yagui, Carlota Oliveira; Izidoro, Mario A.; Cezari, Maria Helena S.; Juliano, Luiz; Chin, Chung Man; Menezes, Carla M. S.; Ferreira, Elizabeth Igne (Taylor & Francis Ltd, 2014)

Evaluation of quinoxaline compounds as ligands of a site adjacent to S2 (AS2) of cruzain

Fabian, Lucas Emanuel; Martini, María Florencia; Salas Sarduy, Emir; Estrin, Dario Ariel; Moglioni, Albertina Gladys (Elsevier, 2019-08)

The binding of ten quinoxaline compounds (1–10) to a site adjacent to S2 (AS2) of cruzain (CRZ) was evaluated by a protocol that include a first analysis through docking experiments followed by a second analysis using the ...

Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor

Assis, Diego Magno; Gontijo, Vanessa Silva; Pereira, Ivan de Oliveira; Santos, Jorge Alexandre Nogueira; Camps, Ihosvany; Nagem, Tanus Jorge; Ellena, Javier; Izidoro, Mario Augusto; Tersariol, Ivarne Luis dos Santos; Barros, Nilana Meza Tenório de; Doriguetto, Antonio Carlos; Santos, Marcelo Henrique dos; Juliano, Maria Aparecida (Informa HealthcareLondon, 2013-08)

Cruzain is the major cysteine protease of Trypanosoma cruzi, the infectious agent responsible for Chagas disease, and cruzain inhibitors display considerable antitrypanosomal activity. In the present work we elucidated ...

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain

Espíndola, José Wanderlan Pontes; Cardoso, Marcos Veríssimo de Oliveira; Oliveira Filho, Gevanio Bezerra de; Silva, Dayane Albuquerque Oliveira e; Moreira, Diogo Rodrigo Magalhaes; Bastos, Tanira Matutino; Simone, Carlos Alberto de; Soares, Milena Botelho Pereira; Villela, Filipe Silva; Ferreira, Rafaela Salgado; Castro, Maria Carolina Accioly Brelaz de; Pereira, Valéria Rego Alves; Murta, Silvane Maria Fonseca; Sales Junior, Policarpo Ademar; Romanha, Alvaro José; Leite, Ana Cristina Lima (Editions Scientifiques Elsevier, 2016)

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.

Espíndola, José Wanderlan Pontes; Cardoso, Marcos Veríssimo de Oliveira; Oliveira Filho, Gevanio Bezerra de; Silva, Dayane Albuquerque Oliveira e; Moreira, Diogo Rodrigo Magalhães; Bastos, Tanira Matutino; Simone, Carlos Alberto de; Soares, Milena Botelho Pereira; Villela, Filipe Silva; Ferreira, Rafaela Salgado; Castro, Maria Carolina Accioly Brelaz de; Pereira, Valeria Rego Alves; Murta, Silvane Maria Fonseca; Sales Junior, Policarpo Ademar; Romanha, Alvaro Jose; Leite, Ana Cristina Lima (Elsevier, 2016)

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Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Convergent synthesis and cruzain inhibitory activity of novel 2-(N `-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi

Evaluation of quinoxaline compounds as ligands of a site adjacent to S2 (AS2) of cruzain

Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain

Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.