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Intrastromal injection of bevacizumab in patients with corneal neovascularization
(Conselho Brasileiro de Oftalmologia, 2012-08-01)
Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate ...
Corneal angiogenesis based on different protocols of alkaline cauterization in murine models
(2017-01-01)
Purpose: To establish and compare protocols of alkaline cauterization for inducing corneal angiogenesis in murine models. Methods: Twenty-four adult Wistar rats were distributed into four groups (G1, G2, G3, and G4). The ...
In vivo effect of bevacizumab-loaded albumin nanoparticles in the treatment of corneal neovascularization
(Academic Press Ltd - Elsevier Science Ltd, 2019-08)
Corneal neovascularization (CNV) is associated with different ocular pathologies, including infectious keratitis, trachoma or corneal trauma. Pharmacological treatments based on the topical application of anti-VEGF therapies ...
Effect of metronidazole ophthalmic solution on corneal neovascularization in a rat model
(2018-04-26)
Purpose: To evaluate the effect of metronidazole ophthalmic solutions on corneal neovascularization (CNV) in a rat model. Methods: A chemical burn was created in the right central cornea of 40 rats. Animals were randomized ...
Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization
(BioMed Central, 2015-02)
Background: To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with ...
In vitro characterization of new stabilizing albumin nanoparticles as a potential topical drug delivery system in the treatment of corneal neovascularization (CNV)
(Editions Sante, 2019-08)
The aim of this work was to study the preparation process and the in vitro release of human serum albumin nanoparticles stabilized by Gantrez® ES-425, which was loaded with antiangiogenic drugs (suramin and bevacizumab). ...
Biocompatibility of Ferrara intracorneal ring segment with and without chondroitin sulfate coating: Clinical and histopathological evaluation in rabbits
(2013-09-01)
PURPOSE: To investigate and compare the biocompatibility of two types of Ferrara intracorneal ring segment: with and without chondroitin sulfate coating by clinical and histopathological evaluation. METHODS: A randomized ...
Biocompatibility of Ferrara intracorneal ring segment with and without chondroitin sulfate coating: Clinical and histopathological evaluation in rabbits
(2013-09-01)
PURPOSE: To investigate and compare the biocompatibility of two types of Ferrara intracorneal ring segment: with and without chondroitin sulfate coating by clinical and histopathological evaluation. METHODS: A randomized ...
Synthetic stigmasterol derivatives inhibit capillary tube formation, herpetic corneal neovascularization and tumor induced angiogenesis
(Elsevier Science Inc, 2016-09)
Angiogenesis plays a critical role in initiating and promoting several diseases, such as cancer and herpetic stromal keratitis (HSK). Herein, we studied the inhibitory effect of two synthetic stigmasterol derivatives on ...
Synthetic stigmasterol derivatives inhibit capillary tube formation, herpetic corneal neovascularization and tumor induced angiogenesis: antiangiogenic stigmasterol derivatives
(Elsevier Inc, 2016-11)
Angiogenesis plays a critical role in initiating and promoting several diseases, such as cancer and herpetic stromal keratitis (HSK). Herein, we studied the inhibitory effect of two synthetic stigmasterol derivatives on ...