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AMPK-dependent nitric oxide release provides contractile support during hyperosmotic stress
(Dr Dietrich Steinkopff Verlag, 2018-01)
In different pathological situations, cardiac cells undergo hyperosmotic stress (HS) and cell shrinkage. This change in cellular volume has been associated with contractile dysfunction and cell death. Given that nitric ...
Experimental assessment of a myocyte-based multiscale model of cardiac contractile dysfunction
(Academic Press Ltd - Elsevier Science Ltd, 2018-11)
Cardiac contractile dysfunction (CD) is a multifactorial syndrome caused by different acute or progressive diseases which hamper assessing the role of the underlying mechanisms characterizing a defined pathological condition. ...
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated with Sepsis
(Lippincott Williams, 2017-04)
Objectives: Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic reticulum Ca2+ loss that mediate altered ...
Ejaculatory dysfunction in streptozotocin-induced diabetic rats: the role of testosterone
(Polish Acad Sciences Inst PharmacologyKrakowPolónia, 2011)
Myocardial contractile dysfunction contributes to the development of heart failure in rats with aortic stenosis
(Elsevier B.V., 2007-04-12)
Objectives: To analyze the potential contribution of contractility state and ventricular geometry to the development of heart failure in rats with aortic stenosis.Methods: Rats were divided into three groups: compensated ...