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Network analysis of dynamically important residues in protein structures mediating ligand-binding conformational changes
(Springer, 2019-07)
According to the generalized conformational selection model, ligand binding involves the co-existence of at least two conformers with different ligand-affinities in a dynamical equilibrium. Conformational transitions between ...
On the analysis and comparison of conformer-specific essential dynamics upon ligand binding to a protein
(American Institute of Physics, 2015-06)
The native state of a protein consists of an equilibrium of conformational states on an energy landscape rather than existing as a single static state. The co-existence of conformers with different ligand-affinities in a ...
Conformational changes, from β-strand to α-helix, of the fatty acid-binding protein ReP1-NCXSQ in anionic lipid membranes: dependence with the vesicle curvature
(Springer, 2017-07)
We studied the conformational changes of the fatty acid-binding protein ReP1-NCXSQ in the interface of anionic lipid membranes. ReP1-NCXSQ is an acidic protein that regulates the activity of the Na+/Ca2+ exchanger in squid ...
Binding of the substrate UDPglucuronic acid induces conformational changes in the xanthan gum glucuronosyltransferase
(Oxford University Press, 2016-06)
GumK is a membrane-associated glucuronosyltransferase of Xanthomonas campestris that is involved in xanthan gum biosynthesis. GumK belongs to the inverting GT-B superfamily and catalyzes the transfer of a glucuronic acid ...
Effect of Solvent-Induced Coil to Helix Conformational Change on the Two-Photon Absorption Spectrum of Poly(3,6-phenanthrene)
(AMER CHEMICAL SOCWASHINGTON, 2012)
This paper investigates the effect of solvent-induced conformational changes of poly(3,6-phenanthrene) on their two-photon absorption (2PA). Such effect was studied employing the wavelength-tunable femtosecond Z-scan ...
Fatty acid and retinol-binding protein: Unusual protein conformational and cavity changes dictated by ligand fluctuations
(American Chemical Society, 2019-07-31)
Lipid-binding proteins (LBPs) are soluble proteins responsible for the uptake, transport, and storage of a large variety of hydrophobic lipophilic molecules including fatty acids, steroids, and other lipids in the cellular ...
Protons induce calsequestrin conformational changes
(Biophysical Society, 1996)
Calsequestrin, a high-capacity, intermediate-affinity, calcium-binding protein present in the lumen of sarcoplasmic reticulum, undergoes extensive calcium-induced conformational changes at neutral pH that cause distinct ...
Kinase Activation by Small Conformational Changes
(American Chemical Society, 2019-11)
Protein kinases (PKs) are allosteric enzymes that play an essential role in signal transduction by regulating a variety of key cellular processes. Most PKs suffer conformational rearrangements upon phosphorylation that ...