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Metabolic Network design of Synechocystis sp. PCC 6803 to obtain bioethanol under autotrophic conditions
(Elsevier Science, 2017-10)
In this work, we propose a genomic scale metabolic network model of the genetically engineered Synechocystis sp. PCC 6803 within a bilevel programming framework to study ethanol photosynthetic production. The model is ...
Estudo da injeção de água e alteração da razão volumétrica de compressão para mitigação da detonação e melhoria do desempenho de um motor de combustão interna
(Universidade Federal de Minas GeraisUFMG, 2018-07-20)
The numerical simulation of an internal combustion engine is an important tool for the development of new technologies constantly integrating the automotive sector to improve engine performance. In this work, water injection ...
Phospholipase D δ knock-out mutants re tolerant to severe drought stress
(Taylor & Francis, 2015-06)
Phospholipase D (PLD) is involved in different plant processes, ranging from responses to abiotic and biotic stress to plant development. Phospholipase Dδ (PLDδ) is activated in dehydration and salt stress, producing the ...
Reduced nerve injury-induced neuropathic pain in kinin B-1 receptor knock-out mice
(Soc Neuroscience, 2005-03-02)
Injury to peripheral nerves often results in a persistent neuropathic pain condition that is characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is accompanied by a local inflammatory reaction in ...
GABAB1 knock-out mice reveals alteration in prolactin levels, gonadotropin axis and reproductive function
(Karger, 2005-12)
gamma-Aminobutyric acid (GABA) has been implicated in the control of hypophyseal functions. We evaluated whether the constitutive loss of functional GABA(B) receptors in GABA(B1) knockout (GABA(B1)(-/-)) mice alters hormonal ...
Positive regulation of raphe serotonin neurons by serotonin 2B receptors
(Nature Publishing Group, 2018-06)
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors ...
Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation
(Federation of American Societies for Experimental Biology, 2017-11)
Galectin-8 (Gal-8) is a mammalian β-galactoside-binding lectin, endowed with proinflammatory properties. Given its capacity to enhance antigen-specific immune responses in vivo, we investigated whether Gal-8 was also able ...
Systems biology and chemoinformatics methods for biomining and systems metabolic engineering applications
(Universidad de Chile, 2014)
In the first chapter, this thesis aims to demonstrate the great potential of Constraint-Based Reconstruction and Analysis (COBRA) methods for studying and predicting specific phenotypes in the bacterium Acidithiobacillus ...
GABAB receptors in neuroendocrine regulation
(Springer, 2008-09)
Gamma-amino butyric acid (GABA), in addition to being a metabolic intermediate and the main inhibitory neurotransmitter in the synaptic cleft, is postulated as a neurohormone, a paracrine signaling molecule, and a trophic ...