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Botanical drug clinical trial: common issues and future options
Botanical drugs are plant-derived, complex mixtures which may have synergistic effects.
In order to understand this disparity between human use and drugs approved by regulatory agencies,
we analyzed botanical drug clinical ...
Differences between the real and the desired worlds in the results of clinical trials
(2015-01-01)
OBJECTIVE: We refer to the effectiveness (known as pragmatic or real world) and efficacy (known as explanatory or desired or ideal world) of interventions. However, these terms seem to be randomly chosen by investigators ...
Committees for ethics in research involving human subjects
(2008-03-01)
In Brazil since October 1996 there have been guidelines for research involving human subjects. Now human subjects know when their treatment is part of research. Deceit is no longer tolerated. But is not enough to say we ...
Committees for ethics in research involving human subjects
(2008-03-01)
In Brazil since October 1996 there have been guidelines for research involving human subjects. Now human subjects know when their treatment is part of research. Deceit is no longer tolerated. But is not enough to say we ...
Metformin for the treatment of breast cancer: Protocol for a scoping review of randomised clinical trials
(2021-08-09)
Introduction Innovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic ...
Comparison of the effects of sodium bicarbonate jet prophylaxis on blood pressure in normotensive individuals and patients with controlled hypertension: A controlled clinical trial
(2017-07-01)
This study assessed the blood pressure (BP) of normotensive subjects and subjects with pharmacologically controlled hypertension after sodium bicarbonate jet prophylaxis. Forty subjects were divided into 2 groups: A ...
Computer-aided design and computer-aided manufacturing indirect versus direct composite restorations: A randomized clinical trial
(2021-01-01)
Objective: This study compared the clinical performance of large indirect restorations (IRs) versus direct restorations (DRs) in posterior teeth. Methods: Thirty subjects received two class II restorations (n = 60), one ...
Acupuncture in migraine prophylaxis: a randomized sham-controlled trial
(Blackwell PublishingOxfordInglaterra, 2006)