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Mild versus severe COVID-19: Laboratory markers
The number of COVID-19 patients is dramatically increasing worldwide. Treatment in intensive care units
(ICU) has become a major challenge; therefore, early recognition of severe forms is absolutely essential
for timely ...
A minimal common outcome measure set for COVID-19 clinical research
Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research
efforts are often hastily organised and done using various research tools, with the result that pooling ...
An ounce of prevention and a pound of cure: Randomized clinical trials of therapeutics against COVID-19 and an assessment of personal protective equipment and distancing
Given the multitudinous clinical characteristics of SARSCoV-2 infection (the cause of the COVID-19 pandemic),
the medical profession’s early response to managing
afflicted patients effectively amounted to throwing ...
Association Between the "COVID-19 Occupational Vulnerability Index" and COVID-19 Severity and Sequelae Among Hospital Employees
Objectives: In addition to personal and health related factors, healthcare workers have an increased risk due to their work. We assessed the association of the score of the Occupational Vulnerability Index with the risk ...
Tocilizumab in COVID-19: Enthusiasm vs. evidence
(Wolters Kluwer Health, 2021)
Based on the pathophysiological characterization of COVID-19, initial studies suggested the use of tocilizumab (TCZ), a recombinant humanized monoclonal antibody of the immunoglobulin G1 class, for management of the cytokine ...
An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics
Since a novel coronavirus pneumonia outbreak in late December 2019,
coronavirus disease -19 (COVID-19) epidemic has gradually spread worldwide,
becoming a major public health event. No specific antivirals are currently ...
Free DNA, a reason for severe COVID-19 infection?
The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2
infection (COVID-19) has a bad clinical outcome, and some reports ...
Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019
Objective: To explore the clinical value of immune-inflammatory markers to assess the severity of
coronavirus disease 2019 (COVID-19).
Methods: 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled ...
Clinical analysis of risk factors for severe COVID-19 patients with type 2 diabetes
Aims: To describe characteristics of COVID-19 patients with type 2 diabetes and to analyze risk factors for severity.
Methods: Demographics, comorbidities, symptoms, laboratory findings, treatments and outcomes of ...
Androgen sensitivity gateway to COVID-19 disease severity
(2020-01-01)
In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID-19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while ...