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Tumor-stroma interaction increases CD147 expression in neoplastic B lymphocytes in chronic lymphocytic leukemia
(Academic Press Inc Elsevier Science, 2020-05)
Chronic lymphocytic leukemia (CLL) microenvironment plays a critical role in disease pathogenesis. Matrix metalloproteinases (MMPs) are involved in CLL-B cell migration and survival. CD147 is associated with MMPs production ...
Immunoregulatory effects of Lurbinectedin in chronic lymphocytic leukemia
(Springer, 2020-02-13)
Despite significant therapeutic improvements chronic lymphocytic leukemia (CLL) remains an incurable disease and there is a persistent pursuit of new treatment alternatives. Lurbinectedin, a selective inhibitor of active ...
Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia
(Taylor & Francis, 2002-02)
The progressive accumulation of B-cell chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to resistance to apoptosis, although this can be modulated in vitro by a variety of cellular and humoral factors ...
Lipoprotein lipase expression in chronic lymphocytic leukemia: new insights into leukemic progression
(MDPI, 2017)
Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. Due to its catalytic activity, LPL is involved in metabolic pathways exploited by various solid and hematologic malignancies to provide an extra energy ...
CXCL12 is a costimulator for CD4+ T cell activation and proliferation in chronic lymphocytic leukemia patients
(Springer, 2013-01)
Activated T cells from patients with chronic lymphocytic leukemia (CLL) provide survival and proliferative signals to the leukemic clone within lymphoid tissues. Recruitment of both, CLL cells and T lymphocytes, to this ...
Spontaneous apoptosis in chronic lymphocytic leukemia and its relationship to clinical and cell kinetic parameters
(Wiley-lissNew YorkEUA, 2001)
Increased expression of autophagy protein LC3 in two patients with progressing chronic lymphocytic leukemia
(Frontiers Media, 2020-07)
Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the western hemisphere. It is characterized by a clonal proliferation of a population of CD5+ B lymphocytes that accumulate in the secondary ...
Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment
(Nature Publishing Group, 2013-03)
We have previously demonstrated that lipoprotein lipase (LPL) is associated to an unmutated immunoglobulin profile and clinical poor outcome in Chronic Lymphocytic Leukemia (CLL). Despite the usefulness of LPL for CLL ...
Methylation status regulates LPL expression in Chronic Lymphocytic Leukemia
(Taylor & Francis Ltd, 2013-08)
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite ...