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Gestational hypoxia and blood-brain barrier permeability: early origins of cerebrovascular dysfunction induced by epigenetic mechanisms

Herrera Videla, Emilio Augusto; González Candia, Manuel Alejandro (Frontiers Media, 2021)

Fetal chronic hypoxia leads to intrauterine growth restriction (IUGR), which is likely to reduce oxygen delivery to the brain and induce long-term neurological impairments. These indicate a modulatory role for oxygen in ...

Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep

González Candia, Alejandro; Véliz, Marcelino; Araya, Claudio; Quezada, Sebastián; Ebensperger Darrouy, Germán; Serón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Mosby-Elsevier, 2016)

BACKGROUND: Intrauterine growth restriction is a condition in which the fetus has a birthweight and/or length <10th percentile for the gestational age. Intrauterine growth restriction can be associated with various causes, ...

Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andean altiplano

Herrera Videla, Emilio; Rojas, Rodrigo T.; Krause, Bernardo J.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Giussani, Dino A.; Parer, Julian T.; Llanos Mansilla, Jorge (WILEY-BLACKWELL, 2016)

High-altitude hypoxia causes intrauterine growth restriction and cardiovascular programming. However, adult humans and animals that have evolved at altitude show certain protection against the effects of chronic hypoxia. ...

Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction

Casanello, Paola; Herrera Videla, Emilio; Krause, Bernardo J. (INTECH, 2017)

Most of the worldwide deaths in patients with non-communicable diseases are due to cardiovascular and metabolic diseases, which are determined by a mix of environmental, genetic and epigenetic factors, and by their ...

Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress

Farías, Jorge; Herrera Videla, Emilio; Carrasco Pozo, Catalina; Sotomayor Zárate, Ramón; Cruz, Gonzalo; Morales Retamales, Paola; Castillo Peñaloza, Rodrigo (Pergamon-Elsevier, 2016)

Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...

Inhibition of peroxisome proliferator gamma (PPARɣ): a potential link between chronic maternal hypoxia and impaired fetal growth

Autor desconocido (Journal of Women's Health, 2013)

Background and Objective: Chronic maternal hypoxia impairs fetal growth and increases the incidence of intrauterine growth restriction (IUGR). To identify the mechanisms underlying these hypoxia-related effects, we evaluated ...

High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep

Herrera Videla, Emilio; Pulgar, Víctor M.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Reyes, Roberto V.; Ebensperger Darrouy, Germán; Parer, Julian T.; Valdéz, Enrique A.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A.; Llanos Mansilla, Jorge (AMER PHYSIOLOGICAL SOC, 2007-06)

Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze consequences of ...

Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the andean altiplano

Autor desconocido (2016)

Expression of vascular endothelial growth factor and endothelial nitric oxide synthase is increased in the placenta of sheep at high altitude in the Andes

Parraguez Gamboa, Víctor; Miljenko, Atlagich; Urquieta, Bessie; Galleguillos, Marco; Reyes Solovera, Mónica de los; Kooyman, David L.; Araneda, Silvia; Raggi Saini, Luis (CANADIAN VET MED ASSOC, 2010-07)

Fetal weight and the placenta of sheep at high altitude (HA) are affected by hypoxia. Placental changes (an increase in placental size and vascularization) are greater in ewes from populations that have lived for several ...

Advances in Fetal and Neonatal Physiology

Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)

The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...