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Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study
(Elsevier, 2014)
BACKGROUND: Clinical effectiveness of previous regimens to treat Plasmodium vivax infection have been hampered by compliance. We aimed to assess the dose-response, safety, and tolerability of single-dose tafenoquine plus ...
Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping
(Oxford University Press, 2015)
UNLABELLED: Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, ...
Hydroxychloroquine and chloroquine in COVID-19: should they be used as standard therapy?
(2020)
The pandemic of the new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has urged the nations to an unprecedented world-wide reaction, including an accelerated exploration of therapeutic ...
Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial
(BioMed Central, 2016)
Background: Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for preventing relapsing Plasmodium vivax infection ...
The possible mechanisms of action of 4-aminoquinolines (chloroquine/ hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?
The anti-malarial drugs chloroquine (CQ) and primarily the less toxic hydroxychloroquine (HCQ) are currently
used to treat autoimmune diseases for their immunomodulatory and anti-thrombotic properties. They have also
been ...
Decoding the silent walk of COVID-19: Halting its spread using old bullets
Severe acute respiratory syndrome (SARS) develops within 3-14 days when CoV2 invades
epithelial, myeloid cells in the nasopharynx and pneumocytes in the respiratory tract through
angiotensin converting enzyme (ACE2). ...
Rhodococcus equi e metabolismo do ferro: associação com susceptibilidade genética e sobrevivência em macrófagos
(Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina Veterinária, 2016-02-17)
Horse breeding industry is an activity in ascension worldwide, and is responsible for generating jobs and income. In Brazil, especially in Rio Grande do Sul state, there are several horse breeding farms with high-standard ...