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The emerging role of amiodarone and dronedarone in Chagas disease. Gustavo Benaim and Alberto E. Paniz Mondolfi
(NATURE REVIEWS | CARDIOLOGY (Nat. Rev. Cardiol), 2013)
Current advances in drug discovery for Chagas disease
(2018-07-15)
Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 million people are infected worldwide, mainly ...
Quimioterapia experimental da doença da chagas: Influência do tratamento específico na regressão das lesões fibrótico - inflamatórias do miocárdio
(Academia de Medicina da Bahia, 2019)
Perspectives for a new drug candidate for Chagas disease therapy
(Fiocruz/IOC, 2022)
Current and developing therapeutic agents in the treatment of Chagas disease
(2010)
Chagas disease must be treated in all its stages: acute, indeterminate, chronic, and initial and middle determinant chronic, due to the fact that DNA of the parasite can be demonstrated by PCR in chronic cases, where optical ...
Chagas disease pharmacotherapy and its chemical structure activity relationship
(2017-01-01)
Therapeutic arsenal currently available for Chagas disease is restricted in only two drugs, nifurtimox and benznidazole, since 1960s and 1970s, respectively. Despite the efforts to develop new drugs, until now, no new drugs ...
Estado actual en el tratamiento de la enfermedad de Chagas
(Sociedad Médica de Santiago, 2011)
The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009)
Among the pathophysiological derangements operating in the chronic phase of Chagas disease, parasite persistence is likely to constitute the main mechanism of myocardial injury in patients with chronic chagasic cardiomyopathy. ...
Current drug therapy and pharmaceutical challenges for Chagas disease
(Elsevier Science, 2016-04)
One of the most significant health problems in the American continent in terms of human health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite Trypanosoma cruzi. Infection was originally ...