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Evidence of cellular senescence during the development of estrogen-induced pituitary tumors
(BioScientifica, 2015-03)
Although pituitary adenomas represent 25% of intracranial tumors, they are usually benign, with the mechanisms by which these tumors usually avoid an invasive profile and metastatic growth development still remaining ...
Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis
(Wiley-Blackwell, 2017-09-01)
Liver fibrosis is a pathophysiological process correlated with intense repair and cicatrization mechanisms in injured liver, and over the past few years, the characterization of the fine-tuning of molecular interconnections ...
Telomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescence
(Elsevier B.V., 2015-05-01)
The identification of biological markers that allow the early diagnosis, or even the prevention of age-related diseases, is an important goal that is being actively pursued in the research community. Sleep is one of the ...
Activities of vacuolar cysteine proteases in plant senescence
(Springer, 2018)
Plant senescence is accompanied by a marked increase in proteolytic activities, and cysteine proteases (Cys-protease) represent the prevailing class among the responsible proteases. Cys-proteases predominantly locate to ...
Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
Krüppel-like Factor 6 is required for oxidative and oncogene-induced cellular senescence
(Frontiers Media S.A., 2019-11)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its ...
Krüppel-like factor 6 Is required for oxidative and oncogene-iduced cellular senescence
(Frontiers Media S.A., 2019-11)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its ...
p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation
(Elsevier Science, 2014-03)
Background: During evolution, organisms with renewable tissues have developed mechanisms to prevent tumorigenesis, including cellular senescence and apoptosis. Cellular senescence is characterized by a permanent cell cycle ...
Senescence Markers in Peripheral Blood Mononuclear Cells in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease
(2022)
Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence ...