Macroautophagy is a physiological cellular process that sequesters senescent or damaged organelles and proteins in autophagosomes for recycling of their products. Autophagy is also involved in the removal of cells that ...

Autophagy plays an important role in human pathologies, such as myopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, ...

Autophagy is an evolutionarily preserved degradation process of cytoplasm cellular constituents, which has been known for its roles in protecting cells against stresses such as starvation and in eliminating defective ...

The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, ...

A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...

Autophagy is a cellular mechanism that protects cells from stress by digesting non-functional cellular components. In the cartilage, chondrocytes depend on autophagy as a principal mechanism to maintain cellular homeostasis. ...