Buscar
Mostrando ítems 1-10 de 4311
Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration
(Springer, 2021-04-28)
Hepatocellular carcinoma is one of the most common types of cancer in the world with high mortality rate and new therapies that control of fatty acid metabolism may limit the proliferation of cancer cells. In the last two ...
The modulatory effect of triclosan on the reversion of the activated phenotype of LX-2 hepatic stellate cells
(Wiley-Blackwell, 2019-11-12)
Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy ...
Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication
(MDPI, 2020)
Zika virus (ZIKV) is a mosquito-borne virus associated with neurological disorders such as
Guillain-Barré syndrome and microcephaly. In humans, ZIKV is able to replicate in cell types from
di erent tissues including ...
Modulation of gap junction channels and hemichannels by growth factors
(2012)
Gap junction hemichannels and cell–cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination ...
Central cellular signaling pathways involved with the regulation of lipid metabolism in the liver: A review
(2020-01-01)
The liver is primarily responsible for energy homeostasis and the regulation of lipid, carbohydrate and protein metabolism. Lipid metabolism consists of distributing lipids to peripheral tissues or ensuring their return ...
Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver
(Taylor & Francis Ltd, 2020-09-14)
Introduction: Non-alcoholic fatty liver disease (NAFLD) affects similar to 25% of world population and cases have increased in recent decades. These anomalies have several etiologies; however, obesity and metabolic ...
Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity
(Elsevier, 2017)
Residency at high altitude (HA) demands adaptation to challenging environmental conditions with hypobaric hypoxia being the most important one. Epidemiological and experimental data suggest that chronic exposure to HA ...