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Signaling pathways involved in neuron-astrocyte adhesion and migration
(2014)
Astrocytes in the normal brain possess a stellate shape reflecting their non-migratory properties. Alternatively, in neurodegenerative diseases or after injury, astrocytes become "reactive" in a process known as astrocytosis ...
Control of cell adhesion and migration by podocalyxin. Implication of Rac1 and Cdc42
(Elsevier, 2013-02-08)
Podocalyxin (PODXL) is a type I membrane sialomucin, originally described in the epithelial cells (podocytes) of kidney glomeruli. PODXL is also found in extra-renal tissues and in certain aggressive tumors, but its precise ...
Guiding cell migration with microscale stiffness patterns and undulated surfaces
(Elsevier, 2016-07)
By placing stiff structures under soft materials, prior studies have demonstrated that cells sense and prefer to position themselves over the stiff structures. However, an understanding of how cells migrate on such surfaces ...
Simvastatin alters fibroblastic cell responses involved in tissue repair
(WILEY-BLACKWELL, 2011)
Background and Objective: Statins have been used to control hypercholesterolemia. However, these drugs also exert pleiotropic effects that include the modulation of inflammation and cell signaling. The present study has ...
Protein tyrosine phosphatase PTP1B in cell adhesion and migration
(Landes Bioscience, 2013-09-12)
Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the ...
K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity
(MDPI, 2020)
Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling. Interestingly, ubiquitination ...
Role of glycosylation in hypoxia-driven cell migration and invasion
(NLM (Medline), 2019)
Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated ...
Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin
(Elsevier Ireland, 2016-07-15)
Breast cancer is the most common malignancy in women, with metastases being the cause of death in 98%. In previous works we have demonstrated that retinoic acid (RA), the main retinoic acid receptor (RAR) ligand, is involved ...
Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts
(AMER ACAD PERIODONTOLOGY, 2008-04)
Background: Platelet-rich plasma is a blood-derived fraction that contains a high concentration of platelets and growth factors. It was proposed that the use of this platelet concentrate stimulates tissue repair. However, ...
Cell Migration and Cell Adhesion Assays to Investigate Leishmania-Host Cell Interaction
(MyJove Corporation, 2021)