Buscar
Mostrando ítems 1-10 de 37
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Blackwell Publishing Ltd, 2016)
© 2016 International Society for Neurochemistry Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's ...
Modulation of the jnk and p38 pathways by cdk5 protein kinase in a transgenic mouse model of alzheimers disease
(LIPPINCOTT WILLIAMS & WILKINS, 2003)
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Wiley-Blackwell, 2016)
Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's disease. Our previous studies revealed that ...
Modulation of the jnk and p38 pathways by cdk5 protein kinase in a transgenic mouse model of alzheimers diseaseNEUROREPORTNEUROREPORT
(LIPPINCOTT WILLIAMS & WILKINS, 2017)
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
(Wiley, 2007)
The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and ...
1α,25 dihydroxi-vitamin D3 modulates CDK4 and CDK6 expression and localization
(Elsevier, 2015-03)
We recently reported that the vitamin D receptor (VDR) and p38 MAPK participate in pro-differentiation events triggered by 1α,25(OH)2-vitamin D3 [1,25D] in skeletal muscle cells. Specifically, our studies demonstrated that ...
Aberrant upregulation of CDK1 contributes to medroxyprogesterone acetate (MPA) resistance in cancer-associated fibroblasts of the endometrium
(2022-11-05)
The response to medroxyprogesterone acetate (MPA) decreases as endometrial disease progresses from the benign to malignancy. In a mouse model, progesterone receptor (PR) expression in normal fibroblasts is accountable for ...
CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions
(Elsevier, 2014-04)
DNA damage, which perturbs genomic stability, has been linked to cognitive decline in the aging human brain, and mutations in DNA repair genes have neurological implications. Several studies have suggested that DNA damage ...
Conditional TNF-alpha Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis
(International & American Associations for Dental Research, 2016)
Tumor necrosis factor-alpha(TNF-alpha) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-alpha expression not only promotes inflammation but can also lead to pain hypersensitivity in nociceptors. ...