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Beyond Pseudo-natural Products: Sequential Ugi/Pictet-Spengler Reactions Leading to Steroidal Pyrazinoisoquinolines That Trigger Caspase-Independent Death in HepG2 Cells
(Wiley VCH Verlag, 2021-06)
In this work, we describe how stereochemically complex polycyclic compounds can be generated by applying a synthetic sequence comprising an intramolecular Ugi reaction followed by a Pictet-Spengler cyclization on steroid-derived ...
CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
(WILEY-BLACKWELL, 2011)
Background. Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. Methods. By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the ...
Copper center dot dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009)
Copper center dot dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
(AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009)
Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species
(Elsevier Ireland, 2016-08)
Flavonoids have attracted great interest due to their possible anticancer activities. Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines ...
Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells
(2017-02-10)
Background: Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxic ...
Prion pathogenesis is independent of Caspase-12
(2007)
The pathogenic mechanism(s) underlying neurodegenerative diseases associated with protein misfolding is unclear. Several studies have implicated ER stress pathways in neurodegenerative conditions, including prion disease, ...
Prion pathogenesis is independent of caspase-12
(Taylor and Francis Inc., 2007)
© 2007 Landes Bioscience. The pathogenic mechanism(s) underlying neurodegenerative diseases associated with protein misfolding is unclear. Several studies have implicated ER stress pathways in neurodegenerative conditions, ...
Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
(ELSEVIER, 2006-06-12)
NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...