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Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris
(Elsevier B.V., 1998-11-01)
In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH2Cl2/MeOH extract from leaves of Casealia ...
Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris
(Elsevier B.V., 1998-11-01)
In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH2Cl2/MeOH extract from leaves of Casealia ...
Optimisation of conditions for the extraction of casearins from Casearia sylvestris using response surface methodology
(Wiley-Blackwell, 2006-05-01)
Optimal conditions for the extraction of casearins from Casearia sylvestris were determined using response surface methodology. The maceration and sonication extraction techniques were performed using a 3 x 3 x 3 full ...
Optimisation of conditions for the extraction of casearins from Casearia sylvestris using response surface methodology
(Wiley-Blackwell, 2006-05-01)
Optimal conditions for the extraction of casearins from Casearia sylvestris were determined using response surface methodology. The maceration and sonication extraction techniques were performed using a 3 x 3 x 3 full ...
Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes
(2019-01-01)
Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in ...
Acidic and hepatic derivatives of bioactive clerodane diterpenes casearins J and O
(2019-09-01)
Clerodane diterpenes from Casearia sylvestris are antiulcerogenic and anti-inflammatory. The finding that they may undergo acid degradation or hepatic metabolization led to an investigation of their degradation products. ...
Casearin X, Its Degradation Product and Other Clerodane Diterpenes from Leaves of Casearia sylvestris: Evaluation of Cytotoxicity against Normal and Tumor Human Cells
(Wiley-v C H Verlag Gmbh, 2010-01-01)
An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, casearin X, together with the known compounds casearins B, D, L, and O, and caseargrewiin F Casearin X degraded to the corresponding ...
Casearin X, Its Degradation Product and Other Clerodane Diterpenes from Leaves of Casearia sylvestris: Evaluation of Cytotoxicity against Normal and Tumor Human Cells
(Wiley-v C H Verlag Gmbh, 2010-01-01)
An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, casearin X, together with the known compounds casearins B, D, L, and O, and caseargrewiin F Casearin X degraded to the corresponding ...
Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis
(Elsevier B.V., 2010-12-05)
Clerodane diterpenes have demonstrated cytotoxic, antiplasmodial and anti-ulcer properties. In the present work, we determined the cytotoxic effect of casearin L (Cas L), O (Cas O) and X (Cas X) and (-)-hardwickiic acid ...