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MicroRNAs associated to anthracycline-induced cardiotoxicity in women with breast cancer: a systematic review and pathway analysis
(COL - SETOR DE PATOLOGIA CLINICAFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE GENÉTICA ECOLOGIA EVOLUÇÃO, 2020)
Background: Cardiotoxicity is a common and serious adverse effect of anthracycline therapy in breast cancer patients. The current criteria for cardiotoxicity are based on imaging and cardiac biomarkers. However, there is ...
Short-term doxorubicin cardiotoxic effects: involvement of cardiac Thyrotropin Releasing Hormone system
(Pergamon-Elsevier Science Ltd, 2020-08)
Doxorubicin is an antineoplastic in the anthracycline class widely used for the treatment of several solid tumors and blood cancers. Cardiotoxicity is the major dose-limiting adverse effect of the drug. Chronic and accumulated ...
Pharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology
(Sage Publications Ltd, 2011-10-01)
The effect of pharmacological dose of cc-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = II) or E (cc-tocopherol, n = II) group. Animals received corn oil ...
Pharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology
(Sage Publications Ltd, 2011-10-01)
The effect of pharmacological dose of cc-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = II) or E (cc-tocopherol, n = II) group. Animals received corn oil ...
Biocompatible microemulsion modifies the pharmacokinetic profile and cardiotoxicity of doxorubicin
(2013-01-01)
Doxorubicin (DOX) is an anthracycline antibiotic with a broad antitumor spectrum. However, the clinical use of DOX is limited because of its cardiotoxicity, a dose-dependent effect. Colloidal drug delivery systems, such ...
Biocompatible microemulsion modifies the pharmacokinetic profile and cardiotoxicity of doxorubicin
(2013-01-01)
Doxorubicin (DOX) is an anthracycline antibiotic with a broad antitumor spectrum. However, the clinical use of DOX is limited because of its cardiotoxicity, a dose-dependent effect. Colloidal drug delivery systems, such ...
Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats
(2016-12-01)
Background: Cardiotoxicity is the major side effect of doxorubicin. As mechanisms that are involved in cardiotoxicity are ambiguous, new methods for attenuating cardiotoxicity are needed. Recent studies have shown that ...
Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
(Springer Verlag, 2016)