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Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
(2017)
Mitochondrial fusion is thought to be important for supporting cardiac contractility, but is hardly detectable in cultured cardio-myocytes and is difficult to directly evaluate in the heart. We overcame this obstacle through ...
CaMKII-dependent responses to ischemia and reperfusion challenges in the heart
(Frontiers, 2014-05)
Ischemic heart disease is a leading cause of death, and there is considerable imperative to identify effective therapeutic interventions. Cardiomyocyte Ca2+ overload is a major cause of ischemia and reperfusion injury, ...
Swimming training attenuates contractile dysfunction in diabetic rat cardiomyocytes
(Arquivos Brasileiros de Cardiologia, 2017)
Fibrosis and hypertrophy induced by Trypanosoma cruzi in a three-dimensional cardiomyocyte-culture system
(Oxford University Press, 2019)
Morphology and contractility in cardiomyocytes of rats with low exercise performance
(Arquivos Brasileiros de Cardiologia, 2017)
Targeting the cardiomyocyte cell cycle for heart regeneration
(Bentham Science Publishers, 2018-08)
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and cytokinesis are infrequent. This makes the heart highly inefficient ...
Application Based On The Canny Edge Detection Algorithm For Recording Contractions Of Isolated Cardiac Myocytes
(Pergamon-Elsevier Science LTDOxford, 2017)