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Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes
(Elsevier, 2020)
Cardiac hypertrophy is an adaptive response to manage an excessive cardiac workload and maintain normal cardiac function. However, sustained hypertrophy leads to cardiomyopathy, cardiac failure, and death. Adrenergic ...
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
(Elsevier, 2016)
Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth
(North Holland PublishingLimerick, 2013-08-25)
Previous studies have indicated that AMP-activated protein kinase (AMPK) plays a critical role in the control of cardiac hypertrophy mediated by different stimuli such as thyroid hormone (TH). Although the classical effects ...
Disarray of sarcomeric alpha-actinin in cardiomyocytes infected by Trypanosoma cruzi
(Cambridge University Press, 2020)
Resistance to cardiomyocyte hypertrophy in ae3−/− mice, deficient in the AE3 Cl− /HCO3 − exchanger
(Biomed Central, 2014-07)
Background: Cardiac hypertrophy is central to the etiology of heart failure. Understanding the molecular pathways promoting cardiac hypertrophy may identify new targets for therapeutic intervention. Sodium-proton exchanger ...
Regulation of cardiomyocyte autophagy by calcium
(Amer Physiological Soc, 2016)
Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...