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Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts
(Elsevier, 2020)
Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac ...
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation
(Elsevier Ltd, 2016)
© 2016 Elsevier Ltd. Cardiac inflammation can be produced by pathogen-associated molecular patterns (PAMPs), from parasitic, bacterial or viral origin; or by danger-associated molecular patterns (DAMPs), released from dead ...
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
(Elsevier, 2016)
© 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
(2011)
Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
Simvastatin induces apoptosis by a rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)