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Downregulation of ATM Gene and Protein Expression in Canine Mammary Tumors
(2016-11-01)
The ataxia telangiectasia mutated (ATM) gene encodes a protein associated with DNA damage repair and maintenance of genomic integrity. In women, ATM transcript and protein downregulation have been reported in sporadic ...
Hormonal Carcinogenesis in Canine Mammary Cancer: Molecular Mechanisms of Estradiol Involved in Malignant Progression
(MDPI, 2021)
Canine mammary cancer corresponds to a tumor disease that frequently affects female dogs, especially those that are reproductively intact. This disease can decrease the survival and quality of life of affected animals; ...
A cyclized peptide derived from α fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells
(2009)
The effects of estradiol (E2) and of an AFP-derived cyclized peptide (cP) on the proliferation of primary cultures of cancer cells isolated from spontaneous canine mammary tumors were studied. The cellular response to E2 ...
Progesterone receptor membrane component 1 (PGRMC1) expression in canine mammary tumors: A preliminary study
(2020-10-01)
Canine mammary tumors (CMT) represent the most common neoplasms in female dogs and their diagnosis and classification relies on histopathological examination. Recently, PGRMC1 has been considered to be a putative biomarker ...
Simvastatin modulates beta-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
(Polska Akad Nauk, 2018)
The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional antitumor treatments as chemo and radiotherapy. It ...
Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
(Spandidos Publications, 2015)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The ...
Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
(Spandidos Publications, 2015)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The ...
Marginal activity of progesterone receptor B (PR-B) in dogs but high incidence of mammary cancer
(Elsevier B.V., 2014-10-01)
Progesterone plays an important role in the normal development and carcinogenesis of the mammary gland. In vitro studies have shown that the canine progesterone receptor B (cPR-B), which is essential for mammary development ...
Association of CD44+/CD24-cells to more aggressive molecular phenotypes in canine mammary carcinomas
(2015-01-01)
Leading the cause of death among female dogs, mammary gland tumor awakes the interest of the scientific community, mostly because the similarities in clinical presentation and evolution to breast cancer in women. Due to ...
Simvastatin modulates β-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
(Polish Academy of Sciences, 2018)
© 2018 Polish Academy of Sciences. All rights reserved. The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional ...