Buscar
Mostrando ítems 1-10 de 59
Prevention of estradiol 17β-d-glucuronide– induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes
(American Society for Cell Biology, 2011-08)
In estradiol 17β-d-glucuronide (E17G)–induced cholestasis, the canalicular hepatocellular transporters bile salt export pump (Abcb11) and multidrug-resistance associated protein 2 (Abcc2) undergo endocytic internalization. ...
Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow
(American Society for Pharmacology and Experimental Therapeutics, 2019-12)
The purpose of this minireview is to show that a new paradigm is developing regarding hepatic bile flow. The focus thus far has been on carrier-mediated transport of bile acids and other solutes, such as glutathione, which ...
Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver
(PORTLAND PRESS, 1999)
The canalicular multispecific organic anion transporter. cMoat, is an ATP-binding-cassette protein expressed in the canalicular domain of hepatocytes. In addition to the transport of endo- and xenobiotics, cMoat has also ...
Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis
(Springer, 2014-06)
At present, it has not been systematically evaluated whether the functional alterations induced by cholestatic compounds in canalicular transporters involved in bile formation can be reproduced in sandwich-cultured rat ...
Aquaporin gene therapy for cholestasis
(John Wiley & Sons Inc, 2017-01)
This is regarding the editorial “Aquaporin gene therapy for disorders of cholestasis?” by Tradtrantip and Verkman.(1) We thank the authors for their comments in our recent studies.(2,3) Nevertheless, we believe that an ...
Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver
(Elsevier Science, 2018-04)
Impaired canalicular secretion due to increased endocytosis and intracellular retention of canalicular transporters such as BSEP and MRP2 is a main, common pathomechanism of cholestasis. Nevertheless, the mechanisms governing ...
Differential expression of canalicular membrane Ca2+/Mg2+-ecto-ATPase in estrogen-induced and obstructive cholestasis in the rat
(MOSBY, INC, 2000)
Extracellular adenosine triphosphate (ATP) may regulate hepatocyte and cholangiocyte functions, and under some conditions it may have deleterious effects on bile secretion and cause cholestasis. The canalicular membrane ...
Physiological concentrations of unconjugated bilirubin prevent oxidative stress‑induced hepatocanalicular dysfunction and cholestasis
(Springer, 2014-11)
Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most ...
Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1999)
These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin ...