Buscar
Mostrando ítems 1-10 de 254
Phospholipase D1 modulates protein kinase C-epsilon in retinal pigment epithelium cells during inflammatory response
(Pergamon-Elsevier Science Ltd, 2016-10)
Inflammation is a key factor in the pathogenesis of several retinal diseases. In view of the essential role of the retinal pigment epithelium in visual function, elucidating the molecular mechanisms elicited by inflammation ...
Protein kinase C modulators enhance angiotensin II desensitization of guinea pig ileum via maxi-K+ channels
(Elsevier B.V., 2002-05-03)
We investigated the role of protein kinase in the desensitization of the angiotensin II induced contraction of guinea pig ileum. in contrast to their antagonistic effects on enzymatic activity, body activation blockers ...
Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors
(Sociedad de Biología de Chile, 2004)
Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Angiotensin II Regulation of Renal Dopamine Uptake and Na+,K+-ATPase Activity
(Karger, 2009-03)
Background/Aims: Angiotensin II (ANG II) decreases dopamine (DA) uptake in renal cortex activating AT1 receptors. We investigated the signaling pathways that mediate this action and the incidence of DA-ANG II interaction ...
Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)(2)] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38(MAPK)/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
(PORTLAND PRESS LTD, 2011)
We have demonstrated previously that the complex bis[(2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N`]copper(II), named [Cu(isaepy)(2)], induces AMPK (AMP-activated protein kinase)-dependent/p53-mediated apoptosis in ...
Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells
(Associação Brasileira de Divulgação Científica, 2000-03-01)
Penetration of Trypanosoma cruzi into mammalian cells depends on the activation of the parasite's protein tyrosine kinase and on the increase in cytosolic Ca2+ concentration. We used metacyclic trypomastigotes, the T. cruzi ...