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Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats
(Elsevier B.V., 2015-10-01)
Occupational toxicology and clinical pharmacology integration will be useful to understand potential exposure-drug interaction and to shape risk assessment strategies in order to improve occupational health. The aim of the ...
CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
(Sociedade Brasileira de Genética, 2018)
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas
(Walter de Gruyter & Co, 2008-01-01)
Background: Uterine leiomyomas are common, benign, smooth muscle tumors representing a significant public health problem. The aim of this study was to investigate CYP17A1, CYP19, and androgen (AR) polymorphisms, their ...
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas
(Walter de Gruyter & Co, 2008-01-01)
Background: Uterine leiomyomas are common, benign, smooth muscle tumors representing a significant public health problem. The aim of this study was to investigate CYP17A1, CYP19, and androgen (AR) polymorphisms, their ...
Widespread distribution of resistance to triazole fungicides in Brazilian populations of the wheat blast pathogen
(2021-02-01)
Fungicides have not been effective in controlling the wheat blast disease in Brazil. An earlier analysis of 179 isolates of Pyricularia oryzae Triticum lineage (PoTl) sampled from wheat fields across six populations in ...
Domain-Swap Dimerization of Acanthamoeba castellanii CYP51 and a Unique Mechanism of Inactivation by Isavuconazole
(Amer Soc Pharmacology Experimental Therapeutics, 2020-12-01)
Cytochromes P450 (P450, CYP) metabolize a wide variety of endogenous and exogenous lipophilic molecules, including most drugs. Sterol 14 alpha-demethylase (CYP51) is a target for antifungal drugs known as conazoles. Using ...
Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations
(Elsevier, 1999)
Many investigators have reported an association between genetic polymorphisms of cytochromes P-450 CYP2E1, CYP1A1
or glutathione S-transferase Mu (GSTM1) and susceptibility to lung cancer. However, pronounced interethnic ...
Molecular confirmation of the linkage between the rhizopus oryzae CYP51A gene coding region and its intrinsic voriconazole and fluconazole resistance
(American Society for Microbiology, 2018-08)
Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant to Candida- and Aspergillus-active antifungal azole ...