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Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP) (Wiley-Blackwell, 2016-04-01)

The pharmacokinetics of tramadol is characterized by a large interindividual variability, which is partially attributed to polymorphic CYP2D6 metabolism. The contribution of CYP3A, CYP2B6, fraction unbound, and other ...

Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats

Universidade de São Paulo (USP); Universidade Estadual Paulista (Unesp) (Elsevier B.V., 2015-10-01)

Occupational toxicology and clinical pharmacology integration will be useful to understand potential exposure-drug interaction and to shape risk assessment strategies in order to improve occupational health. The aim of the ...

Genetic polymorphisms of CYP2D6, CYP1A1 and CYP2E1 in the South-Amerindian population of Chile

Munoz, S; Vollrath, V; Vallejos, MP; Miquel, JF; Covarrubias, C; Raddatz, A; Chianale, T (LIPPINCOTT WILLIAMS & WILKINS, 1998)

Polymorphisms of cytochrome P450 genes show pronounced interethnic variation and have not been previously studied in the South-Amerindian population, which probably has an Asian origin. Therefore, a similar distribution ...

Statin regulation of CYP3A4 and CYP3A5 expression

WILLRICH, Maria Alice Vieira; HIRATA, Mario Hiroyuki; HIRATA, Rosario Dominguez Crespo (FUTURE MEDICINE LTD, 2009)

CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by ...

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population

Coura, Renata dos; Marques, Christiane de Fátima Silva; Koifman, Rosalina J.; Koifman, Sergio; Cabello, Pedro Hernan; Hatagima, Ana (Sociedade Brasileira de Genética, 2018)

Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican populationRelevancia de la ancestría para la variabilidad de polimorfismos de las enzimas metabolizadoras de fármacos CYP2C9, CYP2C19 y CYP2D6 en una población multiétnica de Costa Rica

Céspedes-Garro, Carolina; Rodrigues-Soares, Fernanda; Jiménez-Arce, Gerardo; G. Naranjo, María-Eugenia; Tarazona-Santos, Eduardo; Fariñas, Humberto; Barrantes, Ramiro; Llerena, Adrián (Universidad de Costa Rica, 2016)

Niveles de expresión de citocromos P450 (CYP6AA7, CYP4C52v1, CYP6BY3, CYP9J34, CYP9M10, CYP9J40 y CYP9AL1) determinados por RT-qPCR en larvas de Culex quinquefasciatus expuestas a diversos insecticidas.

Rodríguez Sánchez, Iram Pablo (2015)

DIFERENCIAS DE LAS FRECUENCIAS DE LOS POLIMORFISMOS DEL CYP3A41B Y CYP3A53,6 Y 7 ENTRE AMERINDIOS HUICHOLES, CORAS Y TARAHUMARAS

Q.F.B. REYES ROSALES, LAURA MARÍA (2011-06-14)

Have been reported many genetic polymorphisms that affect the functionality of the CYP450 enzymes, which are a major cause of adverse effects or therapeutic failure by drugs.CYP3A4 and CYP3A5 are the most important isoforms ...

Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer

Vidigal, Veronica Marques [UNIFESP]; Silva, Tiago Donizetti [UNIFESP]; de Oliveira, Juliana [UNIFESP]; Marques Pimenta, Celia Aparecida [UNIFESP]; Felipe, Aledson Vitor [UNIFESP]; Forones, Nora Manoukian [UNIFESP] (Wichtig Publishing, 2017)

Introduction: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer ...

CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people

Quiñones Sepúlveda, Luis; Lucas, D.; Godoy, J.; Cáceres Lillo, Dante; Berthou, F.; Varela Figueroa, Nelson; Lee, K.; Acevedo, C.; Martínez, L.; Gil, Lionel; Aguilera, A. M. (Elsevier, 2001)

CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val ...

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