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Solar uv radiation-induced dna bipyrimidine photoproducts: Formation and mechanistic insights
(Springer Verlag, 2015)
Quantification of Cyclobutane Pyrimidine Dimers Induced by UVB Radiation in Conidia of the Fungi Aspergillus fumigatus, Aspergillus nidulans, Metarhizium acridum and Metarhizium robertsii
(WILEY-BLACKWELL, 2010)
Conidia are responsible for reproduction, dispersal, environmental persistence and host infection of many fungal species. One of the main environmental factors that can kill and/or damage conidia is solar UV radiation. ...
Functional acclimation to solar UV-B radiation in Gunnera magellanica, a native plant species of southernmost Patagonia
(Wiley Blackwell Publishing, Inc, 2003-12)
The ecosystems of Tierra del Fuego (in southern Patagonia, Argentina) are seasonally exposed to elevated levels of ultraviolet-B radiation (UV-B: 280-315 nm), due to the passage of the 'ozone hole' over this region. In the ...
Biflavonoids from Araucaria angustifolia protect against DNA UV-Induced damage
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Ultraviolet radiation is one of the most deleterious forms of radiation to terrestrial organisms and is involved in formation of mutagenic pyrimidine dimers and oxidized nucleotides. The biflavonoid fraction (BFF), extracted ...
Major roles of for pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation
(Elsevier B.V., 2017-03-21)
We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but ...
p53 Mutant Human Glioma Cells Are Sensitive to UV-C-Induced Apoptosis Due to Impaired Cyclobutane Pyrimidine Dimer Removal
(AMER ASSOC CANCER RESEARCH, 2009)
The p53 protein is a key regulator of cell responses to DNA damage, and it has been shown that It sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the extrinsic apoptotic pathway, whereas it ...
Chemiexcitation and Its Implications for Disease
(Elsevier Sci Ltd, 2018)
Quantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In ...
The relative roles of DNA damage induced by UVA irradiation in human cells
(Royal Society of ChemistryCambridge, 2013-08)
UVA light (320–400 nm) represents approximately 95% of the total solar UV radiation that reaches the Earth’s surface. UVA light induces oxidative stress and the formation of DNA photoproducts in skin cells. These photoproducts ...
Defective transcription/repair factor IN recruitment to specific UV lesions in trichothiodystrophy syndrome
(AMER ASSOC CANCER RESEARCH, 2008)
Most trichothiodystrophy (TTD) patients present mutations in the xeroderma pigmentosum D (XPD) gene, coding for a subunit of the transcription/repair factor IIH (TFHH) complex involved in nucleotide excision repair (NER) ...
DNA Dosimetry Assessment for Sunscreen Genotoxic Photoprotection
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Due to the increase of solar ultraviolet radiation (UV) incidence over the last few decades, the use of sunscreen has been widely adopted for skin protection. However, considering the high efficiency of ...