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Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents
(BioMed Central, 2019-02)
Background: Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds ...
Tumor Associated Stromal Cells Play a Critical Role on the Outcome of the Oncolytic Efficacy of Conditionally Replicative Adenoviruses
(Public Library of Science, 2009-04)
The clinical efficacy of conditionally replicative oncolytic adenoviruses (CRAd) is still limited by the inefficient infection of the tumor mass. Since tumor growth is essentially the result of a continuous cross-talk ...
Enhanced CRAd activity using artificial enhancers including nucleosome positioning sequences and Wnt-responsive elements
(2013)
Cancer development involves changes driven by the epigenetic machinery, including nucleosome positioning. Recently, the concept that adenoviral replication may be driven by tumor specific promoters (TSPs) gained support, ...
Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to melanoma microenvironment
(Williams & Wilkins, 2013-11)
We have previously designed a conditionally replicative oncolytic adenovirus (CRAd) named Ad-F512 that can target both the stromal and the malignant melanoma cell compartments. The replication capacity of this CRAd is ...
Enhanced CRAd Activity Using Enhancer Motifs Driven by a Nucleosome Positioning Sequence
(Nature Publishing Group, 2013-04)
Cancer development involves changes driven by the epigenetic machinery, including nucleosome positioning. Recently, the concept that adenoviral replication may be driven by tumor specific promoters (TSPs) gained support, ...
Caracterización y desarrollo de promotores quimera que permitan la replicación viral específica en el entorno tumoralDesign and characterization of chimeric promoters that allow specific viral replication within tumor stroma
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2010)
Enhanced CRAd activity using artificial enhancers including nucleosome positioning sequences and Wnt-responsive elements
(2013)
Cancer development involves changes driven by the epigenetic machinery, including nucleosome positioning. Recently, the concept that adenoviral replication may be driven by tumor specific promoters (TSPs) gained support, ...
CRAD - Mata seca: coletânea I
(Universidade Federal de Minas GeraisBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASUFMGPantanal Editora, 2021)