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Avaliação da inibição da atividade da fosfolipase citoplasmática A2 (cPLA2) sobre o ciclo de multiplicação do Vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2017-03-31)
Vaccinia virus (VACV), the prototype virus of the Poxviridae family, is an enveloped virus that carries out its multiplicative cycle entirely in the cytoplasm of the host cell. Throughout its multiplication cycle, VACV ...
PTH and phospholipase A2 in the aging process of intestinal cells
(Wiley-liss, Div John Wiley & Sons Inc, 2004-12)
In this study we analyzed, for the first time, alterations in phospholipase A2(PLA2) activity and response to parathyroid hormone (PTH) in rat enterocytes with aging. We found that PTH, rapidly stimulate arachidonic acid ...
Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases
(2008-09-01)
The effects of myotoxin III (MT-III), a phospholipase A2 (sPLA2) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ...
1α,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: Activation of cytosolic PLA2
(Pergamon-Elsevier Science Ltd, 2004-05)
In the current study, we have probed the role of cytosolic phospholipase A2 (cPLA2) activity in the cellular response to the calciotropic hormones, 1α,25,dihydroxy-vitamin D3 [1α,25(OH)2D 3] and PTH. Stimulation of rat ...
Centella asiatica water extract inhibits iPLA(2) and cPLA(2) activities in rat cerebellum
(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2008)
Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders. Asiaticoside is ...
Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX
(Elsevier Ireland, 2020-06)
Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) ...
NF-κB inhibitors impair platelet activation responses
(Wiley Blackwell Publishing, Inc, 2009-12)
Background: Although platelets are anucleated cells, they express several transcription factors that exert non-genomic functions, including the positive and negative regulation of platelet activation. NF-κB is a major ...
Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E-2 and D-2 and expression of cyclooxygenases
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
The effects of myotoxin III (MT-III), a phospholipase A(2) (sPLA(2)) from Bothrops asper snake venom, and crotoxin B (CB), a neurotoxic and myotoxic sPLA2 from the venom of Crotalus durissus terrificus, on cyclooxygenases ...