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Effects of selective versus non- selective cox-2 inhibition on experimental periodontitis
(2019-03-01)
In the present study we compared the effects of the selective COX-2 inhibitor etoricoxib with those of the classical non-selective NSAID diclofenac on the inflammatory process and alveolar bone loss in an experimental model ...
Antiinflamatórios não-hormonais: inibidores da ciclooxigenase 2
(Sociedade Brasileira de Pediatria, 2006-11-01)
OBJECTIVE: To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects. SOURCES: MEDLINE and ...
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model
(ELSEVIER SCIENCE INC, 2010)
Objective: To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis. Design: Pharmacologic ...
Estudos de modelagem molecular de lignanas em complexos com ciclooxigenases-1 e 2
(Universidade Estadual Paulista (Unesp), 2016-05-11)
Os inibidores seletivos da ciclooxigenase-2 (COX-2), como o rofecoxibe (2) e o celecoxibe (1), formam uma importante classe de medicamentos anti-inflamatórios desenvolvidos a partir da descoberta das duas isoformas das ...
COX Inhibition Profiles and Molecular Docking Studies of the Lignan Hinokinin and Some Synthetic Derivatives
(2018-01-01)
Encouraged by the anti-inflammatory activity of hinokinin in vivo, which is also observed for the analogues dinitrohinokinin and diidrocubebin, herein we used in vitro and in silico methods to assess their selectivity ...
Hepatotoxicity induced by coxibs: how concerned should we be?
(Informa Healthcare, 2016-11)
Introduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we ...
Implicancia de las prostaglandinas en la fisiopatología de la endometriosisRole of prostaglandins in the pathophysiology of endometriosis
(SAEGRE, 2012-11)
Las prostaglandinas son lípidos bioactivos que poseen múltiples y variadas funciones. En biología reproductiva, participan en la regulación de la ovulación, en la fisiología endometrial y en el proceso de menstruación. ...
Mecanismos envolvidos na hipoalgesia induzida por inibidores seletivos de ciclooxigenase-2 em modelos de inflamação em pata de ratos
(Universidade Federal de Minas GeraisUFMG, 2012-03-09)
The aim of this work was elucidated the mechanism involved in hypoalgesic response induced by selective inhibitors of COX-2 (ICOX-2). Hyperalgesia induced by carrageenan (250 g) was modified by pre-treatment with three ...
Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats
(Faculdade De Odontologia De Bauru - USP, 2010)
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process. The non-steroidal anti-inflammatory drugs (NSAIDs) ...
Nitridergic Modulation of COX-2 Efficacy
(2022)
Pain is a common unpleasant sensory and emotional experience, in which are frequently used in their treatment the nonsteroidal anti-inflammatory drugs (NSAIDs). A group of agents with antipyretic, analgesic, and anti-inflammatory ...