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Correlates of efavirenz exposure in chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor
(2013)
OBJECTIVE: To explore the effect of demographics and single-nucleotide polymorphisms in cytochrome P450 (CYP) 2B6, 2A6, UDP-glucuronosyltransferase (UGT) 2B7, and the constitutive androstane receptor (CAR) genes on efavirenz ...
Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse
(ELSEVIER SCIENCE BV, 2007)
Cholestasis is characterized by hypercholesterolemia and the appearance of an abnormal lipoprotein, lipoprotein X (LpX), in plasma. The mechanisms responsible for this cholestatic plasma lipid phenotype are not fully ...
Fitoterápicos e potenciais interações medicamentosas na terapia do câncer
(Sociedade Brasileira de ToxicologiaSão Paulo, 2008)
Atualmente o tratamento dos cânceres, em sua grande maioria, é considerado como um dos problemas mais desafiadores da medicina. A partir do momento que a neoplasia primária metastatiza pelo corpo do hospedeiro o prognóstico ...
The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia
(Wiley-blackwellHobokenEUA, 2013)
Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts
(ELSEVIER SCIENCE INC, 2009)
The nuclear bile acid receptor, farnesoid X receptor (FXR), may play a pivotal role in liver fibrosis. We tested the impact of genetic FXR ablation in four different mouse models. Hepatic fibrosis was induced in wild-type ...
Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs
(FUTURE MEDICINE LTD, 2009)
This report focuses on the effects of cholesterol on the expression and function of the ATP-binding cassette (ABCB1, ABCG2 and ABCC2) and solute-linked carrier (SLCO1B1 and SLCO2B1) drug transporters with a particular focus ...
Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics
(Academic Press Inc Elsevier Science, 2016-07)
The multidrug resistance-associated protein 2 (MRP2/ABCC2) is a transporter that belongs to the ATP-binding cassette (ABC) superfamily. In the intestine, it is localized to the apical membrane of the enterocyte and plays ...
Cytochrome P450 3A expression and function in liver and intestinal mucosa from dexamethasone-treated sheep
(Wiley Blackwell Publishing, Inc, 2012-08)
The effects of repeated administrations of dexamethasone (DEX) (3mg/kg/day by IM route for 7days) on the gene expression profile of a cytochrome P450 (CYP) 3A28-like isoenzyme, on the expression of a CYP3A-immunoreactive ...