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Experimental problems in the application of UV/visible based methods as the quantification tool for the entrapped/released insulin from PLGA carriers
(John Wiley & Sons Ltd, 2009-12)
Background: Controlled release of medicaments from biodegradable polymers remains the most convenient way for their sustained release. Although a number of articles have been published, experimental work involving the ...
Drug Release from Microspheres and Nanospheres of Poly(lactide-co-glycolide) without Sphere Separation from the Release Medium
(Soc Brasileira QuimicaSao PauloBrasil, 2010)
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment
(American Association for the Advancement of Science, 2014-09)
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events. Its hyperactivity is associated with depression. Although enhanced excitatory input to the LHb ...
Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules
(Royal Society of Chemistry, 2016-06)
A combination of mass spectrometry, Raman microspectroscopy, circular dichroism and X-ray crystallography has been used to obtain detailed information on the reaction of an iridium-based CO-releasing molecule (Ir-CORM), ...
Interaction between proteins and Ir based CO releasing molecules: Mechanism of adduct formation and CO release
(American Chemical Society, 2014-10)
Carbon monoxide releasing molecules (CORMs) have important bactericidal, anti-inflammatory, neuroprotective, and antiapoptotic effects and can be used as tools for CO physiology experiments, including studies on vasodilation. ...
Development of a modified-release hydrophilic matrix system of a plant extract based on co-spray-dried powders
(Elsevier Science, 2013-03)
The aim of this paper was to develop a modified-release solid dosage form containing a plant extract, namely Hamamelis virginiana extract. To this purpose, a co-spray-dried powder consisting of H. virginiana extract, ...
Preparation and physicochemical characterization of drug loaded in castor oil-based polyurethane
(Springer, 2020-02-01)
Castor oil is an environmentally friendly alternative to hydrocarbon-based feedstocks for the synthesis of polyurethanes due to its major constituent, ricinoleic acid. This work aimed to obtain and characterize castor ...
Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand
(Amer Chemical Soc, 2011-03-21)
A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray ...
Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand
(Amer Chemical Soc, 2011-03-21)
A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray ...
PLGA based drug delivery systems (DDS) for the sustained release of insulin: Insight into the protein/polyester interactions and the insulin release behavior
(John Wiley & Sons Ltd, 2010-12)
BACKGROUND: Drug delivery systems (DDS) were designed using insulin as model drug and poly (lactic-co-glycolic) copolymers (PLGA) as polymeric matrix. The carriers were synthesized by direct self-assembly of the insulin ...