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Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2-and gamma-secretase inhibitors
(Ferrata Storti FoundationPaviaItália, 2010)
CIGB-300 anticancer peptide regulates the protein kinase CK2-dependent phosphoproteome
(Springer, 2020-05-13)
Casein-kinase CK2 is a Ser/Thr protein kinase that fosters cell survival and proliferation of malignant cells. The CK2 holoenzyme, formed by the association of two catalytic alpha/alpha’ (CK2α/CK2α’) and two regulatory ...
Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2
(Elsevier France-editions Scientifiques Medicales Elsevier, 2013-07)
Herein we describe the synthesis and properties of substituted phenylaminopyrrolo[1,2-a]quinoxaline-carboxylic acid derivatives as a novel class of potent inhibitors of the human protein kinase CK2. A set of 15 ...
Protein kinase CK2 in cancer energetics
(Frontiers Media, 2020)
Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...
Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription
(NATL ACAD SCIENCES, 2006-10-10)
Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
T. cruzi DNA polymerase beta (Tcpol beta) is phosphorylated in vitro by CK1, CK2 and TcAUK1 leading to the potentiation of its DNA synthesis activity
(Public Library Science, 2021)
The unicellular protozoan Trypanosoma cruzi is the causing agent of Chagas disease which
affects several millions of people around the world. The components of the cell signaling
pathways in this parasite have not been ...
Protein kinase CK2 in postsynaptic densities: Phosphorylation of PSD-95/SAP90 and NMDA receptor regulation
(2004)
Protein kinase CK2 (CK2) is highly expressed in rat forebrain where its function is not well understood. Subcellular distribution studies showed that the catalytic subunit of CK2 (CK2α) was enriched in postsynaptic densities ...
Protein Kinase CK2 in Cancer Energetics
(Frontiers Media S.A., 2020-06)
Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...
Structure of the regulatory subunit of CK2 in the presence of a p21(WAF1) peptide demonstrates flexibility of the acidic loop
(BLACKWELL MUNKSGAARD, 2004-10)
A truncated form of the regulatory subunit of the protein kinase CK2beta ( residues 1 - 178) has been crystallized in the presence of a fragment of the cyclin-dependent kinase inhibitor p21(WAF1) ( residues 46 - 65) and ...
Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription
(2006)
Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...