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The structure and evolution of cisregulatory regions: The shavenbaby story
(The Royal Society, 2013-12)
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We ...
The Footprint of Polygenic Adaptation on Stress-Responsive Cis-Regulatory Divergence in the Arabidopsis Genus
(Oxford University Press, 2016-08)
Adaptation of a complex trait often requires the accumulation of many modifications to finely tune its underpinning molecular components to novel environmental requirements. The investigation of cis-acting regulatory ...
Cis-regulatory variation in the shavenbaby gene underlies intraspecific phenotypic variation, mirroring interspecific divergence in the same trait
(Wiley Blackwell Publishing, Inc, 2020-12)
Despite considerable progress in recent decades in dissecting the genetic causes of natural morphological variation, there is limited understanding of how variation within species ultimately contributes to species differences. ...
Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong?
(Oxford University Press, 2013-06)
Transposable elements (TEs) are mobile genetic sequences that can jump around the genome from one location to another, behaving as genomic parasites. TEs have been particularly effective in colonizing mammalian genomes, ...
Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function
(Elsevier, 2018-03)
Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions drive gene expression in defined spatiotemporal ...
Comparative Genomics, Evolution, and Drought-Induced Expression of Dehydrin Genes in Model Brachypodium Grasses
(MDPI, 2021-12)
Dehydration proteins (dehydrins, DHNs) confer tolerance to water-stress deficit in plants. We performed a comparative genomics and evolutionary study of DHN genes in four model Brachy-podium grass species. Due to limited ...
Molecular mechanisms involved in functional macroevolution of plant transcription factors
(Wiley Blackwell Publishing, Inc, 2020-12)
Transcription factors (TFs) are key components of the transcriptional regulation machinery. In plants, they accompanied the evolution from unicellular aquatic algae to complex flowering plants that dominate the land ...
Enhancer turnover and conserved regulatory function in vertebrate evolution
(The Royal Society, 2013-12)
Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor ...
Estructura y función de la región regulatoria de la transcripción del gen shavenbaby en Drosophila melanogasterStructure and function of the cis-regulatory of shavenbaby gene in Drosophila melanogaster
(2018-03-16)
Los programas genéticos del desarrollo en organismos multicelulares son regulados por cambios en la expresión génica. Estos cambios determinan los procesos de diferenciación celular que suceden durante el desarrollo de los ...