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KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells
(Public Library of Science, 2019-01)
The process of neuronal differentiation is associated with neurite elongation and membrane biogenesis, and phosphatidylcholine (PtdCho) is the major membrane phospholipid in mammalian cells. During neuroblast differentiation, ...
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells
(Public Library of Science (PLOS), 2021)
Choline Kinase alpha Expression during RA-induced Neuronal Differentiation: role of C/EBPβ
(Elsevier, 2014-04)
Neuronal differentiation is a complex process characterized by a halt in proliferation and extension of neurites from the cell body. This process is accompanied by changes in gene expression that mediate the redirection ...
Circadian Regulation and Clock-Controlled Mechanisms of Glycerophospholipid Metabolism from Neuronal Cells and Tissues to Fibroblasts
(Humana Press, 2021-10-26)
Along evolution, living organisms developed a precise timekeeping system, circadian clocks, to adapt life to the 24-h light/dark cycle and temporally regulate physiology and behavior. The transcriptional molecular circadian ...
Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice
(ELSEVIER ESPANA, 2021)
Introduction and Objectives: Nonalcoholic-fatty-liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Mineralocorticoid receptor (MR) activation is associated with increased risk of ...
ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q(10) deficiency
(CELL PRESS, 2008)
Muscle coenzyme Q(10) (CoQ(10) or ubiquinone) deficiency has been identified in more than 20 patients with presumed autosomal-recessive ataxia. However, mutations in genes required for CoQ(10) biosynthetic pathway have ...
Identification of novel transcriptional regulators of PKA subunits in Saccharomyces cerevisiae by quantitative promoter-reporter screening
(Wiley Blackwell Publishing, Inc, 2016-08)
The cAMP-dependent protein kinase (PKA) signaling is a broad pathway that plays important roles in the transduction of environmental signals triggering precise physiological responses. However, how PKA achieves the cAMP-signal ...
Expression of phosphatidylcholine biosynthetic enzymes during early embryogenesis in the amphibian Bufo arenarum
(Cambridge University Press, 2013-11)
In the principal route of phosphatidylcholine (PC) synthesis the regulatory steps are catalysed by CTP:phosphocholine cytidylyltransferase (CCT) and choline kinase (CK). Knock-out mice in Pcyt1a (CCT gene) and Chka1 (CK ...
Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions
(American Society for Biochemistry and Molecular Biology, 2013-05-02)
Circadian clocks regulate the temporal organization of several biochemical processes including lipid metabolism and their disruption leads to severe metabolic disorders. Immortalized cell lines acting as circadian clocks ...