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Effect of cholesterol-poly(N,N-dimethylaminoethyl methacrylate) on the properties of stimuli-responsive polymer liposome complexes
(Elsevier Science, 2013-04)
The development of new polymer–liposome complexes (PLCs) as delivery systems is the key issue of this work. Three main areas are dealt with: polymer synthesis/characterization, liposome formulation/characterization and ...
Endocytosis and intracellular traffic of cholesterol-PDMAEMA liposome complexes in human epithelial-like cells
(Elsevier Science, 2017-08)
Liposomes are generally used as delivery systems, as they are capable of encapsulating a wide variety of molecules (i.e. plasmids, recombinant proteins, therapeutic drugs). However, liposomal drug delivery have to fulfill ...
Stabilization of polymer lipid complexes prepared with lipids of lactic acid bacteria upon preservation and internalization into eukaryotic cells
(Elsevier Science, 2014-09)
The physicochemical characterization of polymer liposome complexes (PLCs) prepared with lipids of lactic acid bacteria and poly(N,N-dimethylaminoethyl methacrylate) covalently bound to cholesterol (CHO-PDMAEMA) was carried ...
Graft copolymers based on Poly(2-(dimethylamino)ethyl methacrylate) and Poly(ethyleneimine): synthesis and evaluation as vectors for DNA transfection
(Bogotá - Ciencias - Doctorado en Ciencias - QuímicaDepartamento de QuímicaUniversidad Nacional de Colombia - Sede Bogotá, 2020-02-14)
The first chapter reviews the most important aspects of the polymeric vectors used in gene therapy. This type of therapy involves the introduction of genetic material into specific cells to treat certain diseases, using ...
Caracterización de copolímeros en bloque conjugados como vehículos nanoestructurados para Anfotericina B
(Bogotá - Ciencias - Maestría en Ciencias - QuímicaDepartamento de QuímicaUniversidad Nacional de Colombia - Sede Bogotá, 2020-04-07)
La Anfotericina B (AmB) es un antifúngico de amplio espectro de acción, su actual administración se encuentra limitada por su toxicidad relacionada con su autoagregación al ser una molécula anfifílica. El uso de micelas ...