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Adaptive changes in the rat hippocampal glutamatergic neurotransmission are observed during long-term treatment with lorazepam
(Springer, 2003-12)
Rationale: Chronic treatment with benzodiazepines induces tolerance to most of their pharmacological effects. The best-studied neurochemical correlation to this phenomenon involves GABAergic adaptive changes. However, some ...
Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T-84 Human Intestinal Epithelial Cells
(2015)
The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T-84 cell ...
Multidrug-resistant protein inhibitor and phosphodiesterase inhibitor potentiate the vasodilator effect induced by photobiomodulation in isolated aortic rings
(2022-03-01)
A previous work indicates that the red LASER (660 nm) induces vascular relaxation by nitric oxide (NO)–dependent mechanism. NO activates soluble guanylate cyclase (sGC) which produces cGMP, the main effector in the ...
Role Of Inos-no-cgmp Signaling In Modulation Of Inflammatory And Myelination Processes
(Elsevier Inc., 2014)
Estudo da modulação da via PI3Kγ/AKT/NOS/NO/GCs/GMPc e canais para potássio sobre a dor neuropática em ratos submetidos a constrição do nervo ciático
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2021-05-10)
Neuropathic pain is induced by an injury to the somatosensory nervous system closely related to
changes in defective neuronal plasticity, which keeps the pain chronic and intense. Associated with
maladaptive plasticity ...