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An image analysis method to quantify CFTR subcellular localization
(Academic Press Ltd-elsevier Science Ltd, 2014-02)
Aberrant protein subcellular localization caused by mutation is a prominent feature of many human diseases. In Cystic Fibrosis (CF), a recessive lethal disorder that results from dysfunction of the Cystic Fibrosis Transmembrane ...
CFTR activity and mitochondrial function
(Elsevier B.V., 2013)
Abstract: Cystic Fibrosis(CF)isafrequentandlethalautosomalrecessivedisease,causedbymutationsinthe
gene encodingtheCysticFibrosisTransmembraneConductanceRegulator(CFTR).Beforethediscovery
of the CFTR gene, severalhypoth ...
Cystic fibrosis transmembrane regulator (CFTR) in human trophoblast BeWo cells and its relation to cell migration
(Elsevier, 2014-02)
Introduction: ENaC and CFTR are coexpressed in epithelia and have positive or negative functional interactions. In addition, ENaC and CFTR promote migration in placental trophoblastic cells and human airway cells, respectively. ...
CFTR modulates RPS27 gene expression using chloride anion as signaling effector
(Elsevier Science Inc, 2017-09)
In Cystic Fibrosis (CF), the impairment of the CFTR channel activity leads to a variety of alterations, including differential gene expression. However, the CFTR signaling mechanisms remain unclear. Recently, culturing ...
The expression of the mitochondrial encoded gene ND4 is downregulated in cystic fibrosis
(Elsevier, 2007)
Abstract: Cystic fibrosis (CF) is a disease produced by mutations in the CFTR channel. We have previously reported that the CFTR chloride transport activity regulates the differential expression of several genes, including ...
The mitochondrial complex I activity is reduced in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function
(Dominik Hartl, University of Tübingen, Germany, 2012)
Abstract: Cystic fibrosis (CF) is a frequent and lethal autosomal recessive disease. It results from different possible mutations in the CFTR gene, which encodes the CFTR chloride channel. We have previously studied the ...
CFRT is involved in colorectal cancer stem cell phenotype
(Fundación Revista Medicina, 2019)
CFTR is a chloride channel expressed in many epithelial cells and there is a relationship between this channel and cancer. The cancer stem cells (CSC) are responsible of tumorigenesis, secondary focus formation in metastasis ...
Epiregulin (EREG) is upregulated through an IL‐1β autocrine loop in Caco‐2 epithelial cells with reduced CFTR function
(Wiley-liss, Div John Wiley & Sons Inc, 2017-11)
CFTR is a cAMP-regulated chloride channel, whose mutations produce cystic fibrosis. The impairment of CFTR activity increases the intracellular Cl- concentration, which in turn produces an increased interleukin-1β (IL-1β) ...
CFTR impairment upregulates c-Src activity through IL-1β autocrine signaling
(Elsevier Science Inc, 2017-02)
Cystic Fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Previously, we found several genes showing a differential expression in CFDE cells (epithelial ...