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Centrosome Abnormalities and Polyploidy in Murine Mammary Carcinomas with Different Degrees of Hormone Responsiveness
(Taylor & Francis, 2020-05)
Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. This study aimed to evaluate the relationship between polyploidy, centrosome ...
Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study
(Spandidos Publ Ltd, 2017-03-01)
The genetics background underlying the aggressiveness of chondrosarcoma (CS) is poorly understood. One possible cause of malignant transformation is chromosomal instability, which involves an error in mitotic segregation ...
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
(Wiley & Sons, 2016)
Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it ...
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
(WILEY, 2016)
Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it ...
Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis
(BioMed Central, 2008-06-27)
Abstract
Background
Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to ...
Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis
(BIOMED CENTRAL LTD, 2008-06-27)
Background: Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to amphibole forms of asbestos, chrysotile asbestos fail to ...
Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis
(2008-06-27)
Abstract
Background
Chrysotile is considered less harmful to human health than other types of asbestos fibers. Its clearance from the lung is faster and, in comparison to ...
Pan-cancer molecular patterns and biological implications associated with a tumor-specific molecular signature
(Multidisciplinary Digital Publishing Institute, 2021-01)
Studying tissue-independent components of cancer and defining pan-cancer subtypes could be addressed using tissue-specific molecular signatures if classification errors are controlled. Since PAM50 is a well-known, United ...
Instabilidade genômica resultante de alterações teloméricas e centroméricas define a evolução cariotípica do melanoma em um modelo murino
(Universidade Federal de São Paulo (UNIFESP), 2009)
Aneuploidia e instabilidade cromossômica são características da maioria
dos tumores sólidos. Estas alterações podem resultar da segregação
inapropriada dos cromossomos durante a divisões celulares, que pode ocorrer
por ...
Estudio molecular de pacientes colombianos afectados por enanismo esencial
(Universidad del RosarioMaestría en Ciencias con Énfasis en Genética HumanaFacultad de medicina, 2017)
Microcephalic primordial dwarfism syndromes are a group of rare monogenic diseases that are characterized primarily by extreme low stature of prenatal onset and severe microcephaly. In patients who participated in the ...