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Modification of the linker amino acid in the cell-penetrating peptide NickFect55 leads to enhanced pDNA transfection for in vivo applications
(MDPI, 2023-02-20)
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. ...
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from TIRAP
(2012)
In order to develop future therapeutic applications for cell penetrating peptides (CPPs), it is essential to characterize their internalization mechanisms, as they might affect the stability and the accessibility of the ...
The interfacial electrostatic potential modulates the insertion of cell-penetrating peptides into lipid bilayers
(Royal Society of Chemistry, 2018-06)
Cell-penetrating peptides (CPP) are short sequences of cationic amino-acids that show a surprising ability to traverse lipid bilayers. CPP are considered to be some of the most effective vectors to introduce membrane-impermeable ...
Mechanistic aspects of CPP-mediated intracellular drug delivery: Relevance of CPP self-assembly
(ELSEVIER, 2006-03)
In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery system. The mechanism for CPP internalisation, which first involves interaction with the extracellular matrix, is followed ...
Insulin-loaded liposomes functionalized with cell-penetrating peptides: influence on drug release and permeation through porcine nasal mucosa
(2021-08-05)
The nasal route is promising for the delivery of insulin for diabetes treatment. Drug loading into delivery systems such as liposomes can improve the bioavailability of insulin for this route. Herein, we address the ...
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from tirap
(KOREAN SOCIETY FOR BIOTECHNOLOGY AND BIOENGINEERING, 2012)
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from tirap
(KOREAN SOCIETY FOR BIOTECHNOLOGY AND BIOENGINEERING, 2012)
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from tirap
(KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING, 2012)