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Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
(1999)
The key target of this study was the tau protein kinase II system (TPK II) involving the catalytic subunit cdk5 and the regulatory component p35. TPK II is one of the tau phosphorylating systems in neuronal cells, thus ...
cdk5 modulates β- and δ-catenin/Pin1 interactions in neuronal cells
(2007)
The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
The Cdk5/p35 complex modulates the activity of the purinergic receptor P2X2
(2017)
We earlier reported that inflammation increases Cdk5 activity, a key protein kinase involved in pain signaling.
Cdk5 sensitizes TRPV1 channel by phosphorylation, causing thermal hyperalgesia. Interestingly, we found ...
p120-catenin is necessary for neuroprotection induced by CDK5 silencing in models of Alzheimer's disease
(Blackwell Publishing Ltd, 2016)
© 2016 International Society for Neurochemistry Cyclin-dependent kinase 5 (CDK5) plays important roles in synaptic function. Its unregulated over-activation has been, however, associated with neurodegeneration in Alzheimer's ...
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
(Wiley & Sons, 2015)
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we ...
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells
(2013)
Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...
Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5 -/- Mice
(2014)
Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly ...
TNF-alpha increases production of reactive oxygen species through Cdk5 activation in nociceptive neurons
(Frontiers Media SA, 2018)
The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. ...